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My experience with 5-HTP
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Simeon_Strangelight Offline
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Post: #26
RE: My experience with 5-HTP
(10-19-2015 06:54 PM)Brodiaga Wrote:  Conclusion so far: I would definitely recommend trying 5-HTP to anybody who suffers from bad mood either occasionally or frequently. I don't know if it's good enough to treat clinical depression, but it seems to work well if you don't feel bad enough to go to a doctor but still want to try something to lift your mood.

Questions to those who have more experience with 5-HTP:

-Is it worth trying to take even more per day, perhaps 300mg?

-Is there a recommended limit to how long you can take this supplement or can you take it pretty much indefinitely? if you take it for a long time, does it stop working or cause any side effects?

Those "placebos" work at a few dozen people I already recommended it to. My entire family is taking it.

However whether the 5-HTP was doing the effect is the question. For most people a good multi like ADAM from Now does the job. Some require more like 5-HTP.

The working dose of 5-HTP is between 50 to 400/500mg. I would not take more.

What many people don't know is that there is actually a major scientific understanding out there on 5-HTP - plenty of studies existing. They are just not financed by big pharma:

http://orthomolecular.org/library/jom/20...3-p167.pdf
One of them
http://www.orthomolecular.org/library/jo...1742072j14
http://science.naturalnews.com/5-Hydroxytryptophan.html
http://science.naturalnews.com/Google-Se...3j534373j8

http://onlinelibrary.wiley.com/doi/10.10...8/abstract

Even Cochrane Library - a cooperative of some 100.000 independent MDs around the world assessed that it's definitely better than a placebo, but more studies are needed. Also the study design has to be orthomolecular (meaning higher doses than 10mg or something like that) and Cochrane is not there yet. [Keep also in mind that Cochrane despite still being conventional in medicine refuses to acknowledge 90% of all medical studies claiming that they are either faulty, manipulated, useless or straight out criminal.]

In any case - what those nutrients do is balance your mood and bring you into your natural equilibrium. They don't give you highs, so taking more does not help, but feel free to experiment. Up to 500mg has been tested long-term and is being taken by people around the world. It's still food, so if you don't react badly to it within the first days, then you won't react badly to it after months. I would certainly stop at 500mg, though usually one takes what is necessary and recommended by orthomolecular medicine.

Also the claims that the body somehow gets used to taking supplements and then stops absorbing nutrients through food is pure bogus. That claim has never been proven and frankly makes no sense. All good supplements can essentially be found in food as well - it just gets absorbed faster and at higher dosage than via food. Whenever you eat something, then the body will still digest it and also absorb the nutrients. If your body has no need of it, then it will discard it usually via urine.

And no - the claim of conventional pharma-docs that you only get expensive urine is bullshit as well.

http://orthomolecular.org/resources/omns/v04n21.shtml

Quote:"Expensive urine." It is an old saw, and one terrific sound byte. Too bad it is also false.

Urine is what is left over after your kidneys purify your blood. If your urine contains, say, extra vitamin C, that vitamin C was in your blood. If the vitamin was in your blood, you absorbed it just fine. It is the absence of water-soluble vitamins in urine that indicates vitamin deficiency. If your body excretes vitamins in your urine, that is a sign that you are well-nourished and have nutrients to spare. That is good.

Here's another way to think of it: Standing at the base of the Hoover Dam looking up, you cannot tell how much water is behind it. However, by observing the overflow spillway, you can tell. If the spillway is dry and dusty, full of tumbleweeds and foxes are making their dens, there has been a drought for some time, and the water level in the dam must be low. If water is pouring down the spillway, the dam must be full. "Waste" indicates fullness, just as an overflowing cup is unmistakably a full cup. Urine spillage of vitamins indicates nutritional adequacy. A lack of water-soluble vitamins in the urine indicates inadequacy.

"Expensive urine," writes veteran nutritional reporter Jack Challem, is "a bizarre argument because a $50 restaurant meal and a bottle of fine wine also lead to expensive urine, but no one seems to be complaining about those things. Numerous studies have shown, however, that vitamin supplements do increase people's blood levels of those nutrients." (1)

Essentially - what you describe Brodiga is what most people tell me after having started at least a basic supplementation regime with good Multi and some added extras like 5-HTP.

Some noticed a remarkable improvement in mood, others just a small one, but they also became aware of more energy, so that's why they are still taking the stuff - because it works.
(This post was last modified: 10-20-2015 06:11 PM by Simeon_Strangelight.)
10-20-2015 06:07 PM
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4profit Offline
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Post: #27
RE: My experience with 5-HTP
Skimmed through the thread, but to all the people asking about using this after ecstasy:

I definitely recommend 5-HTP post-roll to help get serotonin levels back up and avoid the post-roll malaise that most people are usually afflicted with; HOWEVER, do not take ecstasy at the same time as taking 5-HTP, or during the roll, as I have been told from those who have done it that it's not a very fun experience.

Make sure you take it the day after your roll, atleast 12 hours after.
10-21-2015 08:17 PM
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Andreas Offline
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Post: #28
RE: My experience with 5-HTP
Zelcorpion: I bought multivitamins and I'm having very positive results combined with 5-HTP. During the last 3 weeks I cut out the junk food consumption (chocolate and chips) to once per week and I started to have these ups and downs everyday. The vitamins helped me smooth out my overall mood throughout the day and 5-HTP is helping me sleep better. Banana

For guys who are depressed and reading this I encourage you to try this stuff. It's great and it makes a huge difference. Like Zel mentioned before, don't believe the shit that some idiot wrote up in an online magazine because s/he didn't have anything better to write about and never tried it once.

And always check who is sponsoring those ''scientific'' studies about these ''harmful'' supplements that we try.
10-22-2015 03:56 PM
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Simeon_Strangelight Offline
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Post: #29
RE: My experience with 5-HTP
(10-22-2015 03:56 PM)Andreas Wrote:  Zelcorpion: I bought multivitamins and I'm having very positive results combined with 5-HTP. During the last 3 weeks I cut out the junk food consumption (chocolate and chips) to once per week and I started to have these ups and downs everyday. The vitamins helped me smooth out my overall mood throughout the day and 5-HTP is helping me sleep better. Banana

For guys who are depressed and reading this I encourage you to try this stuff. It's great and it makes a huge difference. Like Zel mentioned before, don't believe the shit that some idiot wrote up in an online magazine because s/he didn't have anything better to write about and never tried it once.

And always check who is sponsoring those ''scientific'' studies about these ''harmful'' supplements that we try.

One more satisfied customer. Another net benefit is what you don't see - vitamin C, D3, E, Selenium is directly cutting your chances of getting cancer later in life if you keep taking the multi. There are already studies out there that prove it. Selenium is even admitted by conventional medicine, but you need to take 200mcg which only the good high-potency multis have.
(This post was last modified: 10-22-2015 04:22 PM by Simeon_Strangelight.)
10-22-2015 04:22 PM
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Brodiaga Offline
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Post: #30
RE: My experience with 5-HTP
Does it make any difference if you take 5-HTP with dinner or later, like an hour before sleep? I'm also not sure about taking 2-3 hours after dinner on an empty stomach, so probably dinner time is better, though I haven't experienced any stomach problems.
10-28-2015 10:39 PM
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Rutting Elephant Offline
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Post: #31
RE: My experience with 5-HTP
There is a lot of conflicting information online, but I have noticed it is more effective
-with a small amount of chocolate or something sugary, especially before bed.
-not mixed with a vitamin B supplement. B negates it by preventing its crossing the blood-brain barrier. I read some technical arguments about this controversial claim a while back, but once I found taking the multivitamin at least several hours before 5-HTP worked better for me I stopped investigating. Try it with and without B.
10-29-2015 01:18 AM
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Simeon_Strangelight Offline
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Post: #32
RE: My experience with 5-HTP
Generally I would not recommend taking any single-nutrient high-dosage supplements without taking a high-dosage multi.
Also as a rule of thumb it is better to take it on a full stomach.

I for example know that zinc and some other nutrients make you sick, if you take it on empty stomach.

The reason is simply that the nutrients are being absorbed by the body quickly and to do that, then other nutrients are taken. They either bind with the consumed food which helps or other supplements are needed to balance it.

There are also antogonistic nutrients which rely on each other for absorption. D3 is related to vitamin K. Zinc to Magnesium and other nutrients. That's why the most important basic supplement is a high-dosage multi.

Also it's possible to take those supplements without eating. Whenever I do intermittent fasting, then I take just a 50% reduced multi, magnesium, Omega 3, lecithin, D3. I skip zinc and 50% of my multi, because I know that without food, then it won't do me good while the body tries to digest it.

But this is nothing new and frankly it's not a sign that something is bad with it all. Orthomolecular medicine is not new, there are hundreds of books and thousands of studies published that any side effects are hardly side effects, but just temporary digestion issues or minor reactions of overdosing. There are no known long-term damages unless you take supplements with aspartame and other toxins (90%+ of all supplements have a trojan horse embedded).

Be free to study the information - read books by Andrew Saul and others, then experiment with all you know. Just yesterday someone I know gave a friend of her some l-tryptophan and multi to help her with depression. Within days there was a marked improvement and that acquaintance has asked me to order her some supplements. Case Nr. 78 in my history - orthomolecular MDs meet many more of those people. (And most of those take 70% income cuts to change their practice in order to become orthomolecular - and despite that their numbers are growing around the world.)
10-29-2015 06:56 AM
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Cr33pin Offline
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Post: #33
RE: My experience with 5-HTP
I have been asking about this stuff in the supplement/vitamin thread. Perhaps this thread is best suited for 5-HTP talk.

I bought some Natrol 100 fast dissolve 5-HTP about 3 or 4 day ago and have been taking one tablet every mid morning on a empty stomach. I read on a few other websites doctors usually prescribe 200-300mg a day broken up into 2-3 servings a day.

How are you guys taking this stuff? Empty stomach? Before bed? Once a day?

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10-29-2015 07:39 PM
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Andreas Offline
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Post: #34
RE: My experience with 5-HTP
(10-29-2015 07:39 PM)Cr33pin Wrote:  I have been asking about this stuff in the supplement/vitamin thread. Perhaps this thread is best suited for 5-HTP talk.

I bought some Natrol 100 fast dissolve 5-HTP about 3 or 4 day ago and have been taking one tablet every mid morning on a empty stomach. I read on a few other websites doctors usually prescribe 200-300mg a day broken up into 2-3 servings a day.

How are you guys taking this stuff? Empty stomach? Before bed? Once a day?

I take 200mg one hour before bed and I make sure that I don't eat too much. In my experience the more empty my stomach is the faster it knocks me out to deep sleep (though I presume that melatonin is better for troubled sleepers) and I rarely have the urge to get up and pee if I haven't before sleep.

I don't know if I have any deficiencies but every time I take 5-htp it makes me feel sleepy so I avoid taking it during the day.

The best advice I can give you is to just experiment with low dosages at different times of the day and find what works for you. This shit will last you for months and even years if you buy 100 grams or more.
10-30-2015 07:50 PM
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eatthishomie Offline
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Post: #35
RE: My experience with 5-HTP
(10-29-2015 01:18 AM)Rutting Elephant Wrote:  -with a small amount of chocolate or something sugary, especially before bed.

I just got on dat dere Cell Tech, and dat dere Cell Tech has like 35 grams of sugar per two servings. I'll report back on the effects of taking 5-HTP with dat dere Cell Tech.
10-30-2015 10:39 PM
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swoosh Offline
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Post: #36
RE: My experience with 5-HTP
5-htp is a precusur to serotonin. Taking it sort of let's one hop over the rate limiting step and make more serotonin. It's cool your into nootropics but you have to ask yourself why you are taking it. I tried it and It made me laugh in a wierd way, like inappropriately and I felt sort of wierd.

There are other effective drugs out there for depression such as the newer antidepressants. They actually block the reputake and removal of 5ht in the brain. 5htp will produce serotonin not only in the brain but the body as well. In the brain it's a happy neurotransmitter. In the body it is a hormone and can mess with metabolism and lead to insulin/glucose dysfunction. Simply put, think diabetes and obesity.

I have heard of people using after recreatn with a certain drug that depletes serotonin but otherwise I have heard many say the side effects of 5htp used in the long run suck.

Now melatonin, that's a cool suppliment. It is an extremely potent antioxidant and can reset the circadian rhythm if used properly. Studies also show it helps in muscle formation. Not to mention it knocks me out cold.
10-30-2015 11:59 PM
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Simeon_Strangelight Offline
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Post: #37
RE: My experience with 5-HTP
(10-30-2015 11:59 PM)swoosh Wrote:  5-htp is a precusur to serotonin. Taking it sort of let's one hop over the rate limiting step and make more serotonin. It's cool your into nootropics but you have to ask yourself why you are taking it. I tried it and It made me laugh in a wierd way, like inappropriately and I felt sort of wierd.

There are other effective drugs out there for depression such as the newer antidepressants.

[Image: 3952197-8852364254-tumbl.gif]

Never heard more bullshit. Antidepressants are not even effective based on the yardstick of conventional medicine.

"Take the newest drug my idiotic consumer, because side-effects will be known in months and years. And we have other drugs that help you deal with side effects of those. Ah - have we mentioned that anti-depressants cause depressions, murderous thoughts and an increase in suicide? Don't worry. Take a pill and die early. We don't need to strain the pension system too much, do we?"
(This post was last modified: 10-31-2015 12:07 AM by Simeon_Strangelight.)
10-31-2015 12:05 AM
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swoosh Offline
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Post: #38
RE: My experience with 5-HTP
I'm not saying 5htp is bad, but for christs sake the kids got a big ol bag of serotonin precursor and a scale and he's eating it like candy. (Side note: Nice scale btw). As of now there is no established safe dose for 5htp and no matter how you look at it it is still a "nutritional suppliment" Stack that against years of rigorous trials needed to develop antidepressants, at leases we know they can cause suicide in early treatment.

So you want me to tone it down and discuss more holistic ways of boosting serotonin?

Chocolate.
Excersize
Sleep
Studies show a healthy presence of gut bacteria also produce serotonin, so eat your yogurt and embrace a healthy diet.

If you want to take 5htp you should also buy the highest quality source as back in the day it was found that a contaminant in tyrosine led to something called EMS.
10-31-2015 07:58 AM
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Simeon_Strangelight Offline
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Post: #39
RE: My experience with 5-HTP
(10-31-2015 07:58 AM)swoosh Wrote:  I'm not saying 5htp is bad, but for christs sake the kids got a big ol bag of serotonin precursor and a scale and he's eating it like candy. (Side note: Nice scale btw). As of now there is no established safe dose for 5htp and no matter how you look at it it is still a "nutritional suppliment" Stack that against years of rigorous trials needed to develop antidepressants, at leases we know they can cause suicide in early treatment.

So you want me to tone it down and discuss more holistic ways of boosting serotonin?

Chocolate.
Excersize
Sleep
Studies show a healthy presence of gut bacteria also produce serotonin, so eat your yogurt and embrace a healthy diet.

If you want to take 5htp you should also buy the highest quality source as back in the day it was found that a contaminant in tyrosine led to something called EMS.

If you have side-effects, then take L-Tryptophan at 500-2000mg. That way your body transforms it to 5-HTP when necessary. It is what I would recommend anyway. Usually I tell folk to take Tryptophan and not the already more body-available form of of 5-HTP. That way you don't interfere with the natural digestion cycle of the body.

Of course quality in supplements is important - Swanson, Nowfoods, Youngevity, Awesomesupplements, Mercola, Nutrivene etc. - those are the ones you can trust.

Most big suppplements companies are owned by Big Pharma - GNC etc. - good luck putting your trust in them.
10-31-2015 08:05 AM
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swoosh Offline
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Post: #40
RE: My experience with 5-HTP
"Eatthishomie" The slump in mood when you come off is probably because when you introduce an amount of neurotransmitter into your brain, it adjust itself and gets used to it. An example: (let's make an analogy between happiness derived from neurotransmitters and like'n that to getting pussy). say you go to a country where you have high value, you get tons of easy pussy and so you get used to trying less, life is great. You don't have to work as hard to produce results. Now say you suddenly were relocated to a country where it was hard to swoop girls. Your normal level of game wouldnt produce results and and you would experience a deficiet of pussy. It would take you a few days to adjust and ramp up production of game to equal your previous level of acquiring the puss. Make sense? That's why for a few days you feel like shit.

Lastly. To Zelcorpian, this is a good discussion because it seems you enjoy learning about brain chemistry and biochemistry.

I want to point out that the Cochrain studies were unable to produce acceptable data on the use of 5htp and l tryptophan. So it's hard really to say what these supplements are really capable of especially long term.

I mean there are uses , like I said I have heard of some people using 5htp and tryptophan after a hard weekend of partying to help the brain recover.

Most of the data out there is self reported like in this forum. What works for you might not work for someone else.

If someone is truley depressed though, A.) it's not their fault most of the time & studies show that there can be a structural defect in the way the brain makes happy neurotransmitters.

The reason I brought up antidepressants is because a suppliment is not going to cure someone who is clinically depressed. Chronic Depression is much different animal than feeling the post weekend blues.

Evidence is out there that depression is linked to a lack of BDNF or brain derived neutrophic factor. Antidepressants not only restore the function of norepi, serotonin, and dopamine ( all three are important in regulating feel good mood) but by increasing BDNF the brain actually creates new connections, starts to grow grow brain cells and strenghthens communicating brain cells. Let me know if I get too heavy on the science.

Still I think the best way to improve mood and enhance cognition is to eat well, (no more
Mt dew code red), get 8 hrs of sleep min. Excersise, and challenge your mind, there are a million studies out there that support this.
Healthy habits and moderation, that's what's up.

If that's workin out for you why tinker with some wack ass supplements.

I'm not going to tell you what to do but hopefully I've provided enough info for you guys to decide for yourselves.
10-31-2015 02:04 PM
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