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Chinese Plays God: Human Genetic Engineering
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MaxJames Offline
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Chinese Plays God: Human Genetic Engineering
It is happening!!!!!!
________________________

http://www.nature.com/news/chinese-scien...os-1.17378

Chinese scientists genetically modify human embryos

Rumours of germline modification prove true — and look set to reignite an ethical debate

[Image: 1.17378.jpg]

In a world first, Chinese scientists have reported editing the genomes of human embryos. The results are published in the online journal Protein & Cell and confirm widespread rumours that such experiments had been conducted — rumours that sparked a high-profile debate last month about the ethical implications of such work.

http://link.springer.com/article/10.1007...015-0153-5

In the paper, researchers led by Junjiu Huang, a gene-function researcher at Sun Yat-sen University in Guangzhou, tried to head off such concerns by using 'non-viable' embryos, which cannot result in a live birth, that were obtained from local fertility clinics. The team attempted to modify the gene responsible for β-thalassaemia, a potentially fatal blood disorder, using a gene-editing technique known as CRISPR/Cas9. The researchers say that their results reveal serious obstacles to using the method in medical applications.

"I believe this is the first report of CRISPR/Cas9 applied to human pre-implantation embryos and as such the study is a landmark, as well as a cautionary tale," says George Daley, a stem-cell biologist at Harvard Medical School in Boston, Massachusetts. "Their study should be a stern warning to any practitioner who thinks the technology is ready for testing to eradicate disease genes."

[Image: CRISPR_logo.jpg]

The paper by Huang's team looks set to reignite the debate on human-embryo editing — and there are reports that other groups in China are also experimenting on human embryos.

Problematic gene

The technique used by Huang’s team involves injecting embryos with the enzyme complex CRISPR/Cas9, which binds and splices DNA at specific locations. The complex can be programmed to target a problematic gene, which is then replaced or repaired by another molecule introduced at the same time. The system is well studied in human adult cells and in animal embryos. But there had been no published reports of its use in human embryos.

Huang and his colleagues set out to see if the procedure could replace a gene in a single-cell fertilized human embryo; in principle, all cells produced as the embryo developed would then have the repaired gene. The embryos they obtained from the fertility clinics had been created for use in in vitro fertilization but had an extra set of chromosomes, following fertilization by two sperm. This prevents the embryos from resulting in a live birth, though they do undergo the first stages of development.

Huang’s group studied the ability of the CRISPR/Cas9 system to edit the gene called HBB, which encodes the human β-globin protein. Mutations in the gene are responsible for β-thalassaemia.

Serious obstacles


The team injected 86 embryos and then waited 48 hours, enough time for the CRISPR/Cas9 system and the molecules that replace the missing DNA to act — and for the embryos to grow to about eight cells each. Of the 71 embryos that survived, 54 were genetically tested. This revealed that just 28 were successfully spliced, and that only a fraction of those contained the replacement genetic material. “If you want to do it in normal embryos, you need to be close to 100%,” Huang says. “That’s why we stopped. We still think it’s too immature.”

His team also found a surprising number of ‘off-target’ mutations assumed to be introduced by the CRISPR/Cas9 complex acting on other parts of the genome. This effect is one of the main safety concerns surrounding germline gene editing because these unintended mutations could be harmful. The rates of such mutations were much higher than those observed in gene-editing studies of mouse embryos or human adult cells. And Huang notes that his team likely only detected a subset of the unintended mutations because their study looked only at a portion of the genome, known as the exome. “If we did the whole genome sequence, we would get many more,” he says.

Ethical questions


Huang says that the paper was rejected by Nature and Science, in part because of ethical objections; both journals declined to comment on the claim. (Nature’s news team is editorially independent of its research editorial team.)

He adds that critics of the paper have noted that the low efficiencies and high number of off-target mutations could be specific to the abnormal embryos used in the study. Huang acknowledges the critique, but because there are no examples of gene editing in normal embryos he says that there is no way to know if the technique operates differently in them.

Still, he maintains that the embryos allow for a more meaningful model — and one closer to a normal human embryo — than an animal model or one using adult human cells. “We wanted to show our data to the world so people know what really happened with this model, rather than just talking about what would happen without data,” he says.

But Edward Lanphier, one of the scientists who sounded the warning in Nature last month, says: "It underlines what we said before: we need to pause this research and make sure we have a broad based discussion about which direction we’re going here." Lanphier is president of Sangamo BioSciences in Richmond, California, which applies gene-editing techniques to adult human cells.

Huang now plans to work out how to decrease the number of off-target mutations using adult human cells or animal models. He is considering different strategies — tweaking the enzymes to guide them more precisely to the desired spot, introducing the enzymes in a different format that could help to regulate their lifespans and thus allow them to be shut down before mutations accumulate, or varying the concentrations of the introduced enzymes and repair molecules. He says that using other gene-editing techniques might also help. CRISPR/Cas9 is relatively efficient and easy to use, but another system called TALEN is known to cause fewer unintended mutations.

The debate over human embryo editing is sure to continue for some time, however. CRISPR/Cas9 is known for its ease of use and Lanphier fears that more scientists will now start to work towards improving on Huang's paper. “The ubiquitous access to and simplicity of creating CRISPRs," he says, "creates opportunities for scientists in any part of the world to do any kind of experiments they want.”

A Chinese source familiar with developments in the field said that at least four groups in China are pursuing gene editing in human embryos.

-__________________________________


The Chinese are planning to produce superbabies, which will ensure their total world domination.



You can read more here.

http://www.wsj.com/articles/new-advance-...1429804820

http://www.telegraph.co.uk/news/science/...bryos.html

some of the comment sections

Quote:Mengele thought he was doing a great service to humanity with his experiments, too...

Quote:Ban it? LOL! Bring on the freak show. Now that we've decided homosexual "marriage" is legitimate, Pandora's Box is OPEN.

Quote:Moral, legal, ethical objections aside....'If it can be done by man, it will be done by man'

Quote:What are they afraid of? China may be willing to pursue a eugenic strategy that might make their nation the greatest on Earth, while others pursue anti-eugenic ideologies that are illogical.
Eugenics and genetic engineering could make China the guiding light for all mankind.


Quote:Here we go it seems allowing the powerful agro-chemical interest to force us to have GM foods with unknown health problems ,plus the already current bad effects on the environment and wildlife bio-diversity ,and super weeds taking over so even more powerful chemical needed.Yet when it comes a human embryo shock horror from the God lobby prime time , hypocrisy,which has held back progress to a more enlightened compassionate world back.As it is the claim that we need GM to feed the world is another con,when there is no need for it , when billions of tons of food are wasted ,hundreds of millions of tons grown for bio-fuels annually ,food prices and supplies allowed to be manipulated on the worlds stock markets,money and hypocrisy rule OK...


Quote:Of all the nations on Earth, the Chinese are among the few who openly support eugenics and the advancement of human potential. This is a grand new frontier, and what they're doing is necessary, commendable and courageous. There will always be risks and ethical issues involved in any major scientific project, but as always, if nothing is ventured, then nothing will be gained.
(This post was last modified: 09-23-2015 01:46 PM by MaxJames.)
09-23-2015 01:09 PM
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RE: Chinese Plays God: Human Genetic Engineering
P.S. It's not the Chinese who plan to enslave humanity
09-25-2015 01:16 AM
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MaxJames Offline
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RE: Chinese Plays God: Human Genetic Engineering
(09-25-2015 01:16 AM)Stack Thornehawk Wrote:  P.S. It's not the Chinese who plan to enslave humanity

Pray tell, who does?

The elite will secretly fly their unborn babies to china to create genetically superior babies.

The playing field will grow increasingly steeped.

If you are not born rich or become obscenely rich before this technology is perfected, your children and grandchildren are shit out of luck.

They will be relegated to the shitpile of history.
(This post was last modified: 09-25-2015 08:00 AM by MaxJames.)
09-25-2015 07:59 AM
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RE: Chinese Plays God: Human Genetic Engineering
09-25-2015 09:32 AM
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RE: Chinese Plays God: Human Genetic Engineering
(09-25-2015 09:32 AM)ThrustMaster Wrote:  http://www.imdb.com/title/tt0119177/

It's coming...

Like the other commentator said "If it can be done by man, it will be done by man'".

It is not even a question.

The only remaining question is: who are the winners and losers going to be? Also, which category are you going to end up in?
(This post was last modified: 09-25-2015 01:07 PM by MaxJames.)
09-25-2015 01:06 PM
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RE: Chinese Plays God: Human Genetic Engineering
What makes you think this is a new technology?

http://news.sciencemag.org/biology/2015/...-organisms
(This post was last modified: 09-25-2015 08:55 PM by Easy_C.)
09-25-2015 08:49 PM
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RE: Chinese Plays God: Human Genetic Engineering
If the Chinese begin to allow this generally, tampering with genes to improve babies, beyond what we do - aborting babies with egregious problems - well that will be interesting. It's going to happen, so why not go for it?

Another aspect, it seems, of the west's suicide. "What, improve people with science? Sounds unethical!"

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09-25-2015 09:11 PM
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RE: Chinese Plays God: Human Genetic Engineering
(09-25-2015 08:49 PM)Easy_C Wrote:  What makes you think this is a new technology?

http://news.sciencemag.org/biology/2015/...-organisms


We are talking about two completely different things.

Directed, purposeful genetic engineering is different from what you are talking about.
09-26-2015 01:27 PM
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RE: Chinese Plays God: Human Genetic Engineering
I just read this article in Edge by Geoffrey Miller, an evolutionary psychologist.

He says the number one thing we should be worried about is Chinese Eugenics.

Quote:China has been running the world's largest and most successful eugenics program for more than thirty years, driving China's ever-faster rise as the global superpower. I worry that this poses some existential threat to Western civilization. Yet the most likely result is that America and Europe linger around a few hundred more years as also-rans on the world-historical stage, nursing our anti-hereditarian political correctness to the bitter end.

[...]

Chinese eugenics will quickly become even more effective, given its massive investment in genomic research on human mental and physical traits.

The BGI Cognitive Genomics Project is currently doing whole-genome sequencing of 1,000 very-high-IQ people around the world, hunting for sets of sets of IQ-predicting alleles.

[...]

Given the Mendelian genetic lottery, the kids produced by any one couple typically differ by 5 to 15 IQ points. So this method of "preimplantation embryo selection" might allow IQ within every Chinese family to increase by 5 to 15 IQ points per generation. After a couple of generations, it would be game over for Western global competitiveness.

If the mean IQ of China rises 20-30 points in the next few decades, it's game over for the West.

The Chinese have a strong nationalist spirit. They are willing to go to extreme ends to promote Chinese world dominance. They have access to technology, are red pilled on IQ research, and have no moral qualms about using science to gain a major cognitive advantage.

This is alarming.

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03-19-2017 08:06 PM
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RE: Chinese Plays God: Human Genetic Engineering
From the article:

Quote: Throughout the 1980s, Chinese propaganda urges couples to have children "later, longer, fewer, better"—at a later age, with a longer interval between birth, resulting in fewer children of higher quality. With the 1995 Maternal and Infant Health Law (known as the Eugenic Law until Western opposition forced a name change), China forbade people carrying heritable mental or physical disorders from marrying, and promoted mass prenatal ultrasound testing for birth defects.
Yes and in the process they created a bunch of spoiled and antisocial only children, who will have to begrudgingly take care of multiple elders. China still hasn't solved its biggest problems, among which are creating a country where the air is breathable and where the officialdom isn't hoarding insane amounts of money in overseas holdings or spending it on retarded investments.

Otherwise, a lot of these things we might label as "eugenics" is just good old classicism.
(This post was last modified: 03-19-2017 08:31 PM by Lunostrelki.)
03-19-2017 08:19 PM
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RE: Chinese Plays God: Human Genetic Engineering
(03-19-2017 08:19 PM)Lunostrelki Wrote:  From the article:

Quote: Throughout the 1980s, Chinese propaganda urges couples to have children "later, longer, fewer, better"—at a later age, with a longer interval between birth, resulting in fewer children of higher quality. With the 1995 Maternal and Infant Health Law (known as the Eugenic Law until Western opposition forced a name change), China forbade people carrying heritable mental or physical disorders from marrying, and promoted mass prenatal ultrasound testing for birth defects.
Yes and in the process they created a bunch of spoiled and antisocial only children, who will have to begrudgingly take care of multiple elders. China still hasn't solved its biggest problems, among which are creating a country where the air is breathable and where the officialdom isn't hoarding insane amounts of money in overseas holdings or spending it on retarded investments.

I don't think the ruling elite in China sees any of that as a problem.

Kek memes show us what the power of assembled, weaponised autism can do. Imagine that force directed by a government with citizens who don't question the narrative.

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(This post was last modified: 03-19-2017 08:32 PM by Paracelsus.)
03-19-2017 08:30 PM
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Elster Away
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RE: Chinese Plays God: Human Genetic Engineering
Wasn't it Israel that had the longest running eugenics program?

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03-20-2017 01:50 AM
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RE: Chinese Plays God: Human Genetic Engineering
Damn, it's already difficult to distinguish one Chinese person from another, when they start mass producing clones of their smartest individuals it will be totally impossible.
03-20-2017 04:28 AM
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RE: Chinese Plays God: Human Genetic Engineering
Lol, chinese eugenics.

You guys realize the cultural revolution was the part of their "amazing eugenics program" where they executed and murdered a fuck-ton of the craftsman, intellectuals, and teachers, right? The joke is that they killed all the people smart enough to oppose Mao.

I'm not saying Chinese people are dumb, but most Western people have a really inflated view of Chinese intelligence. The chinese people that you meet abroad are the top-tier Chinese people. A lot of those grocery store owners may look like they're unassuming old dudes, but many of them are loaded out the ass. You guys should see how expensive it is for a chinese person to even get a traveler's visa for USA.

If you met a normal mainlander you wouldn't be terrified of china taking over either.

This is a country where they can't even teach people that spitting on the ground spreads disease and that drinking hot water isn't a cure for STDs (you think i'm kidding but i'm really not), but I'm expected to believe they're going to roll out genome therapy for millions of people at an affordable cost in the next few decades?

Jordan

Whenever I read this fearmongering over Chinese world dominance I chuckle a little.

As much as I love China, it's a 3rd world country dressed up in a 1st world suit.

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03-20-2017 04:42 AM
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RE: Chinese Plays God: Human Genetic Engineering
(03-20-2017 04:42 AM)Fortis Wrote:  This is a country where they can't even teach people that spitting on the ground spreads disease and that drinking hot water isn't a cure for STDs (you think i'm kidding but i'm really not), but I'm expected to believe they're going to roll out genome therapy for millions of people at an affordable cost in the next few decades?

Laugh3
03-20-2017 04:54 AM
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RE: Chinese Plays God: Human Genetic Engineering
(03-19-2017 08:06 PM)Lucky Wrote:  I just read this article in Edge by Geoffrey Miller, an evolutionary psychologist.

He says the number one thing we should be worried about is Chinese Eugenics.

Quote:China has been running the world's largest and most successful eugenics program for more than thirty years, driving China's ever-faster rise as the global superpower. I worry that this poses some existential threat to Western civilization. Yet the most likely result is that America and Europe linger around a few hundred more years as also-rans on the world-historical stage, nursing our anti-hereditarian political correctness to the bitter end.

[...]

Chinese eugenics will quickly become even more effective, given its massive investment in genomic research on human mental and physical traits.

The BGI Cognitive Genomics Project is currently doing whole-genome sequencing of 1,000 very-high-IQ people around the world, hunting for sets of sets of IQ-predicting alleles.

[...]

Given the Mendelian genetic lottery, the kids produced by any one couple typically differ by 5 to 15 IQ points. So this method of "preimplantation embryo selection" might allow IQ within every Chinese family to increase by 5 to 15 IQ points per generation. After a couple of generations, it would be game over for Western global competitiveness.

If the mean IQ of China rises 20-30 points in the next few decades, it's game over for the West.

The Chinese have a strong nationalist spirit. They are willing to go to extreme ends to promote Chinese world dominance. They have access to technology, are red pilled on IQ research, and have no moral qualms about using science to gain a major cognitive advantage.

This is alarming.

When it comes to China, I'd be more afraid of China coming up with a way to fight without sending in troops. Right now they're in a weird spot. The 1-child policy really put a dent in their warmaking capabilities. You can't expect the only son of a family to risk his life in combat.

China does not have any social safety net, so many of the children born of the one child policy are the only breadwinner for grandparents and parents on both sides. If that kid were to die in war then those grandparents and parents would be on the streets at old age.

Now, if China had a way of enforcing global dominance without actually using boots on the ground then I'd be scared because they have no moral compunction against slaughtering other groups if they get in their way.

Caring more about Donald Trump than your bank account is beta.
03-20-2017 05:01 AM
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RE: Chinese Plays God: Human Genetic Engineering
(03-20-2017 05:01 AM)Fortis Wrote:  
(03-19-2017 08:06 PM)Lucky Wrote:  I just read this article in Edge by Geoffrey Miller, an evolutionary psychologist.

He says the number one thing we should be worried about is Chinese Eugenics.

Quote:China has been running the world's largest and most successful eugenics program for more than thirty years, driving China's ever-faster rise as the global superpower. I worry that this poses some existential threat to Western civilization. Yet the most likely result is that America and Europe linger around a few hundred more years as also-rans on the world-historical stage, nursing our anti-hereditarian political correctness to the bitter end.

[...]

Chinese eugenics will quickly become even more effective, given its massive investment in genomic research on human mental and physical traits.

The BGI Cognitive Genomics Project is currently doing whole-genome sequencing of 1,000 very-high-IQ people around the world, hunting for sets of sets of IQ-predicting alleles.

[...]

Given the Mendelian genetic lottery, the kids produced by any one couple typically differ by 5 to 15 IQ points. So this method of "preimplantation embryo selection" might allow IQ within every Chinese family to increase by 5 to 15 IQ points per generation. After a couple of generations, it would be game over for Western global competitiveness.

If the mean IQ of China rises 20-30 points in the next few decades, it's game over for the West.

The Chinese have a strong nationalist spirit. They are willing to go to extreme ends to promote Chinese world dominance. They have access to technology, are red pilled on IQ research, and have no moral qualms about using science to gain a major cognitive advantage.

This is alarming.

When it comes to China, I'd be more afraid of China coming up with a way to fight without sending in troops. Right now they're in a weird spot. The 1-child policy really put a dent in their warmaking capabilities. You can't expect the only son of a family to risk his life in combat.

China does not have any social safety net, so many of the children born of the one child policy are the only breadwinner for grandparents and parents on both sides. If that kid were to die in war then those grandparents and parents would be on the streets at old age.

Now, if China had a way of enforcing global dominance without actually using boots on the ground then I'd be scared because they have no moral compunction against slaughtering other groups if they get in their way.

Interesting observation. I have never thought of this, but it makes sense.

Another social engineering project that has been largely successful is Shenzhen. As some of you know, I have met a couple of the men that started the city back in the early 80s. One of these men has been a mentor of sorts (he is here in Vancouver) and has told me some interesting stories.

On engineering: They had the opportunity to design a city from scratch. They did it from a short, lonely high rise in the middle of farms and fishing villages. They had the government give them special borders which required certain skills and stamps to be allowed to work and live. One of the main consultants in this was Japanese and he pushed them to only allow highly skilled men in tech related fields. This was going to be a clean tech city that would use the border with Hong Kong to get products out to the west.

But they needed women for these men. Men being men, they knew education was not as important as looks, so they allowed low skilled women in as long as they were single and attractive. These women worked the sales jobs, of which SZ employs by the million. Of course, these people had babies and quickly SZ grew in rep to have some beautiful women. But Chinese, by culture, can only talk about tradition. So they always left SZ out because the area has never been known for anything but ugly women.

When foreign modelling agencies began moving in 15 years ago, things changed. Suddenly Chinese agencies saw what their culture had blinded them to. Now things like SZ fashion week are huge.

Of course the borders are open now, so things changed. But its still apparent when you look for it.
03-20-2017 11:24 AM
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RE: Chinese Plays God: Human Genetic Engineering




Designer babies and the future of genetic engineering.
03-20-2017 05:27 PM
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RE: Chinese Plays God: Human Genetic Engineering
This stuff is so awesome.

It's really going to turn the world upside down....super kids of the most brilliant musicians, athletes, scientists!

I hope it's viable for me in a couple decades or so.
03-20-2017 06:58 PM
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RE: Chinese Plays God: Human Genetic Engineering
(03-19-2017 08:30 PM)Paracelsus Wrote:  
(03-19-2017 08:19 PM)Lunostrelki Wrote:  From the article:

Quote: Throughout the 1980s, Chinese propaganda urges couples to have children "later, longer, fewer, better"—at a later age, with a longer interval between birth, resulting in fewer children of higher quality. With the 1995 Maternal and Infant Health Law (known as the Eugenic Law until Western opposition forced a name change), China forbade people carrying heritable mental or physical disorders from marrying, and promoted mass prenatal ultrasound testing for birth defects.
Yes and in the process they created a bunch of spoiled and antisocial only children, who will have to begrudgingly take care of multiple elders. China still hasn't solved its biggest problems, among which are creating a country where the air is breathable and where the officialdom isn't hoarding insane amounts of money in overseas holdings or spending it on retarded investments.

I don't think the ruling elite in China sees any of that as a problem.

Kek memes show us what the power of assembled, weaponised autism can do. Imagine that force directed by a government with citizens who don't question the narrative.

I have a bunch of family members with many problems with eyesight and other issues as well as myself.

So I would like for there to be such technology and germline modification so that any children that I have and others after them will not have the same diseases.

I am happy that such technology exists but also worried given the nature of humanity.
03-20-2017 07:16 PM
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RE: Chinese Plays God: Human Genetic Engineering
Interesting laner. You're running in some legit circles!

I think another part of that puzzle is that many of the HK businessmen housed their mistresses in Shenzhen. It's one of those secrets of the city. If you know where to look (Louhu) you can find buildings full of women who look like they just stepped out of a Thai surgery clinic.

My friend lives in a building full of escorts of and trophy wives. He has cold approached in his elevator and pulled hot girls back. lol

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03-20-2017 07:26 PM
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