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Alex Trebek and his bout with cancer
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Roosh Offline
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Alex Trebek and his bout with cancer
Trebek was diagnosed with pancreatic cancer a while back that seemed to respond to chemo, but it recently came back and he must go through chemo again:





The reproducibility crisis has also affected medicine, meaning that chemo is probably not as effective as patients think.

Quote:Science is facing a "reproducibility crisis" where more than two-thirds of researchers have tried and failed to reproduce another scientist's experiments, research suggests.

This is frustrating clinicians and drug developers who want solid foundations of pre-clinical research to build upon.

From his lab at the University of Virginia's Centre for Open Science, immunologist Dr Tim Errington runs The Reproducibility Project, which attempted to repeat the findings reported in five landmark cancer studies.

"The idea here is to take a bunch of experiments and to try and do the exact same thing to see if we can get the same results."

You could be forgiven for thinking that should be easy. Experiments are supposed to be replicable.

The authors should have done it themselves before publication, and all you have to do is read the methods section in the paper and follow the instructions.

Sadly nothing, it seems, could be further from the truth.

After meticulous research involving painstaking attention to detail over several years (the project was launched in 2011), the team was able to confirm only two of the original studies' findings.

https://www.bbc.com/news/science-environment-39054778

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09-17-2019 05:41 PM
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puckerman Offline
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RE: Alex Trebek and his bout with cancer
Don't forget about High Rollers:





Just look at him. I bet he's glad that most of the episodes of this game show were taped over.
(This post was last modified: 09-17-2019 09:52 PM by puckerman.)
09-17-2019 09:52 PM
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Kid Twist Online
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RE: Alex Trebek and his bout with cancer
I love the guy, he is just a classic man all the way around.

I'll leave my thoughts on different cancers, therapies, and cost for a different thread or time.

But depending on the type of cancer, chemo and radiation is not only effective, it can be curative.

Get your passport ready!
09-17-2019 10:17 PM
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RE: Alex Trebek and his bout with cancer
(09-17-2019 09:52 PM)puckerman Wrote:  Don't forget about High Rollers:





Just look at him. I bet he's glad that most of the episodes of this game show were taped over.

That was actually a decent show. I auditioned for it when I was in college on a a lark. As for his hair, well that was pretty bad ass back in the 70s.

He also hosted a good show called Classic Concentration in the late 80s



09-18-2019 04:47 AM
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spokepoker Offline
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RE: Alex Trebek and his bout with cancer
All my hope towards the betterment and recovery of Alex Trebek. Dude did what he wanted to do, there will never be wheel of fortune without him.

"A stripper last night brought up "Rich Dad Poor Dad" when I mentioned, "Think and Grow Rich""
09-18-2019 05:33 AM
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puckerman Offline
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RE: Alex Trebek and his bout with cancer
He had several short-lived shows in the 1970's. Here is Double Dare:





He was hosting Classic Concentration when he was hosting Jeopardy. Yes, that was a good show.

Someone made a compilation of his game-show openings:



09-18-2019 06:24 AM
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Goldin Boy Offline
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RE: Alex Trebek and his bout with cancer
That's a very aggressive form of cancer, the 5-year survival rate is around 8-9%. If you pray you should definitely keep him in your prayers.

(09-18-2019 05:33 AM)spokepoker Wrote:  All my hope towards the betterment and recovery of Alex Trebek. Dude did what he wanted to do, there will never be wheel of fortune without him.

Pat Sajak hosts Wheel of Fortune. Though one year Alex hosted Wheel and Pat was a contestant.

(08-18-2016 12:05 PM)dicknixon72 Wrote:  ...and nothing quite surprises me anymore. If I looked out my showroom window and saw a fully-nude woman force-fucking an alligator with a strap-on while snorting xanex on the roof of her rental car with her three children locked inside with the windows rolled up, I wouldn't be entirely amazed.
09-18-2019 09:11 AM
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Blake2 Offline
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RE: Alex Trebek and his bout with cancer
The prognosis for pancreatic cancer is poor.....

but on the bright side, he's 79 and had a good life. That's right around the average life expectancy in the USA. He made a lot of money, was famous, has 2 kids. Not bad, all things considered.


Regarding reproducibility, I'm sure a lot of things in life aren't as certain as we think they are.
I guess belief in science, as well as what society tells us in general, takes a certain amount of faith. Sometimes its well placed, other times not.

Sometimes I envy our ancestors that didn't have access to so much information. They lived a harsher existence, but maybe a more satisfying one?

A man should never be ashamed to own that he is wrong, which is but saying in other words that he is wiser today than he was yesterday.
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(This post was last modified: 09-18-2019 09:32 AM by Blake2.)
09-18-2019 09:25 AM
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Bienvenuto Offline
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RE: Alex Trebek and his bout with cancer
We had pancreatic cancer hit my family.

Whenever I mentioned it to Drs, Medics, Nurses -that my step-father had it- they would immediately say: "So you know that he's going to die?" "You know that's fatal right?"
Trying to prepare me I expect.

He held on for a long time. Experimental treatments, cutting edge therapies... but Jesus, the quality of life.
He was a walking skeleton for about 2 years, in constant pain.

The last few months were ugly, not least what it did to his body: which was disgusting. We cared for him at home and he died there.

The man himself was an inspiration to those around him .. given the way that he conducted himself whilst in such pain.
he told me he hadn't ever >really< known the meaning of a suicidal urge.. until his last weeks.

I hope Alex Trebek remains well, and that if the cancer cannot be cured, that he is kept in reasonable comfort by his care regimen.
09-18-2019 09:38 AM
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spokepoker Offline
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RE: Alex Trebek and his bout with cancer
Oh I thought Alex Trebek did wheel of fortune, didn't know he did double dare, I though that was the dude who was scared of messy shit.
No, wait, now I remember, Trebek did jeopardy.
It's been a while since I seen real tv.
For reals though, I truly have his best health in heart, he was a staple in my childhood.

"A stripper last night brought up "Rich Dad Poor Dad" when I mentioned, "Think and Grow Rich""
(This post was last modified: 09-18-2019 09:45 AM by spokepoker.)
09-18-2019 09:44 AM
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RoastBeefCurtains4Me Offline
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RE: Alex Trebek and his bout with cancer
I know there are huge problems with reproducability in science generally, but I don't think it is as bad in the cancer field as in other less rigorous areas like psychology, where reproducability is a joke. Cancer sucks, and cancer treatment sucks, but cancer patients have to take what they can get. There is at least some hope, and more now than ever before.

They have to hold clinical trials for every treatment. First they test a new treatment with patients who have already exhausted all other options, to see if it works at all. Some don't, and these are double blind studies with a control group receiving placebos, so even if it works, some patients get the placebo and miss out on the benefits.

If the first trial shows promise, they have to have many more trials, gradually trying it on patients with less extreme circumstances. Insurance won't cover these treatments, so the clinical trials pay for them. They can be very expensive. My wife's treatment would cost $10-15K/month, but the clinical trial covers it. The treatment she is using is effective, and by rights it should already be given to patients immediately after they finish with conventional chemo, but up to now, this has not been done, because there have been no trials testing usage at this point in treatment. The outcome from her current trial should allow a new trial that tests it at the earlier point in the process.

The insurance will only cover it once there have been trials testing it at every point in the process. Insurance companies are very reluctant to pay such astronomical amounts for treatment, and will only do so when faced with an overwhelming body of evidence that the treatment works with some rate of effectiveness. Even after the period of clinical trials ends, the patient outcomes are tracked over the years.

For many types of cancer, there have not been many new breakthroughs over recent decades. A lot of times, you'll see something like an important new drug was introduced in 1978, and another important drug was introduced in 1992, and that's it. Any other improvements in survival rate are achieved by squeezing out the optimal treatment protocol with the existing drugs, such that the long term survival rate gradually goes up from 37% to 43% using the 1992 drug, due to more effective treatment regimens. It's a matter of creating checklists to ensure consistent treatment approaches, and doing statistical analyses tracking every conceivable factor, to identify what circumstances call for which variations in treatment.

It makes a big difference between cancer centers as well. The highest ranked cancer centers like Mayo and MD Anderson have high volumes, so their procedures are refined, and they have top level talent and people specialized to specific cancer types. If you go to a hospital in an 2nd or 3rd tier city where a general oncologist handles 20-50 cases a year spanning all types of cancer, the percentages for remission, progression free survival time, and overall survival time will be lower.

The differences between top cancer centers and non specialist regional medical centers just goes to show that the available cancer knowledge isn't applied reliably. There's not much you can do about this. It's inevitable that a top cancer center with the best doctors and resources will do better than a small regional hospital with non-elite medical staff.

Besides the weaknesses in the treatment facilities, there are at least a portion of the clinical trials and medical studies that are poorly designed, and whose results are fudged in some way. The pharmaceutical companies are clearly squeezing as much profit as they can. There are some very unlikable people making a lot of money in the cancer treatment industry. However, these kind of problems are part of all human endeavors. Cancer treatment has demonstrated significant increases in longevity over recent decades, and there are a lot of recent breakthroughs in gene therapy and multi-drug cocktails that promise big gains in the next few years.

There are problems with insurance companies refusing to pay for treatments that would clearly help, and with incompetence at every level. Someone like Alex Trebek has the opportunity to get the very best treatment, because he is very rich. He can have doctors available to provide the exact treatment he needs at the most opportune time. He doesn't have to worry about delays in testing and treatment because the cancer recurrence was detected 10 days before Christmas as happened to my wife. He doesn't have to worry about treatments not being covered by insurance and having no clinical trial that offers the best option for treatment. He can use Trump's Right to Try law as long as he's willing to pay the cost out of pocket. He can afford drugs that cost $200K/year if that's the most promising option. He can have 5 different experts in his type of cancer consult together and recommend the best treatment, without waiting for one overworked specialist to squeeze him into their schedule.

Someday, cancer treatments will advance, with far more effective treatments that can be applied reliably by average doctors in average facilities. Until then, it can be a real crap shoot, and the penalty for failure is suffering and death. It is what it is.

If you or a loved one have cancer, go to the best ranked cancer center you can get to, with a specialty in your type of cancer, and educate yourself on the current state of the art for treating that cancer. Participate in clinical trials when you can, especially those where earlier trials have had promising results, and they are now doing followup trials to extend the usage of the treatment. Doing so can increase the cure rate or the survival time significantly, but there are no guarantees.

When you're on the inside of the process, cancer treatment is very ugly. Treatments mostly come down to slashing, burning, and poisoning. (Surgery, Radiation, and Chemo). The cancer patient goes from a healthy, vital person to a shell of their former selves. You will meet healthy looking people who had your cancer 10 or 20 years ago, who tell you to stick with it and keep fighting. However, for people who aren't cured, there are horrible treatments, sudden setbacks, unexpectedly rapid progressions, and some short term victories and good times. It's very hard not to have negative emotions and resentments about the process.

For all the doom and gloom, there is reason for hope. Most cancers have some kind of cure rate, with people returning to a high level of health and quality of life. Even in cases like pancreatic cancer where death is inevitable long term, there can be remissions and extended life. I bet Alex Trebek is very happy to have had his remission and to have been able to go back to a job he loves for a while longer. I don't know his personal situation, but he may have lived to see a grandchild born, or a troubled teenage relative get his life together and on a good track. Even if you aren't cured, remission can give you extra time to live with good quality of life. This is a real blessing.



Cancer definitely sucks. I say to fight while you are able to fight, make sure to handle pain aggressively, and if the end comes, make sure to have the best end of life treatment you can get with a well regarded hospice center. When you look back, you'll have regrets, and see things that were done wrong with terrible results, but you might also look back to see a successful and permanent cure. It's all you can do, and you have to put the rest in God's hands.

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(This post was last modified: 09-18-2019 11:01 AM by RoastBeefCurtains4Me.)
09-18-2019 10:55 AM
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Johnnyvee Offline
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RE: Alex Trebek and his bout with cancer
(09-17-2019 05:41 PM)Roosh Wrote:  Trebek was diagnosed with pancreatic cancer a while back that seemed to respond to chemo, but it recently came back and he must go through chemo again:





The reproducibility crisis has also affected medicine, meaning that chemo is probably not as effective as patients think.

Quote:Science is facing a "reproducibility crisis" where more than two-thirds of researchers have tried and failed to reproduce another scientist's experiments, research suggests.

This is frustrating clinicians and drug developers who want solid foundations of pre-clinical research to build upon.

From his lab at the University of Virginia's Centre for Open Science, immunologist Dr Tim Errington runs The Reproducibility Project, which attempted to repeat the findings reported in five landmark cancer studies.

"The idea here is to take a bunch of experiments and to try and do the exact same thing to see if we can get the same results."

You could be forgiven for thinking that should be easy. Experiments are supposed to be replicable.

The authors should have done it themselves before publication, and all you have to do is read the methods section in the paper and follow the instructions.

Sadly nothing, it seems, could be further from the truth.

After meticulous research involving painstaking attention to detail over several years (the project was launched in 2011), the team was able to confirm only two of the original studies' findings.

https://www.bbc.com/news/science-environment-39054778


To bad he will never be exposed to these options. (Which actually work, both preventatively and therapeutically as well.) Lowering insulin is particularly important with pancreatic cancer btw.





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09-18-2019 12:50 PM
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RE: Alex Trebek and his bout with cancer
As a quick aside, and after a great post from RoastBeef above, just remember that the goalposts are always changing. Typically, all of us are less grateful than we should be, and just like leftists, tend to compare what happens to us versus what is happening to others who have more resources, time, or possibilities - whatever they may be.

I know a part of that is human nature, but the greatest virtue of all may be gratitude because it includes all the others. I think it's also the most lacking in our modern day.

I'm grateful Alex was able to live his life and I think he is too. I'm not saying don't fight if you want to, but is another day, or even 365 more, at age 80 anything compared to what he has lived already, and how he has lived?

You know my answer.

Get your passport ready!
09-18-2019 06:15 PM
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hedonist Offline
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RE: Alex Trebek and his bout with cancer
Pancreatic cancer is a terrible cancer to get... lost someone very close to me with it


Things like this really piss me off though
https://www.northernstar.com.au/news/twe...er/560192/

The Fiber Diffraction Diagnosis (FDD) can unveil cancers, including breast and prostate cancer and melanomas, in a cost-effective, non-invasive procedure by simply studying X-rays of a person's fingernail clippings or skin.

But ‘invention' is not the word the 70-year-old would use to describe the FDD. “It feels like more of serendipitous discovery to me,” Prof James said. “It can't cure, but it will enable the diagnosis of the disease early enough for successful treatment.”

Prof James has conducted tests on more than 4500 samples, with not one returning a false negative reading.



This won an inventor show, I remember reading about more research begin done then.....nothing


Not to mention
https://www.theguardian.com/society/2014...rainforest
Berry was banned

And the wasp in Brazil with venom that killed cancer cells but didn't harm regular tissue
(This post was last modified: 09-18-2019 07:59 PM by hedonist.)
09-18-2019 07:58 PM
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Conquistador Offline
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RE: Alex Trebek and his bout with cancer
I always liked Trebek, but didn't know he had a much younger and beautiful wife.

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09-19-2019 11:59 AM
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Blake2 Offline
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RE: Alex Trebek and his bout with cancer
(09-18-2019 07:58 PM)hedonist Wrote:  Pancreatic cancer is a terrible cancer to get... lost someone very close to me with it


Things like this really piss me off though
https://www.northernstar.com.au/news/twe...er/560192/

The Fiber Diffraction Diagnosis (FDD) can unveil cancers, including breast and prostate cancer and melanomas, in a cost-effective, non-invasive procedure by simply studying X-rays of a person's fingernail clippings or skin.

But ‘invention' is not the word the 70-year-old would use to describe the FDD. “It feels like more of serendipitous discovery to me,” Prof James said. “It can't cure, but it will enable the diagnosis of the disease early enough for successful treatment.”

Prof James has conducted tests on more than 4500 samples, with not one returning a false negative reading.



This won an inventor show, I remember reading about more research begin done then.....nothing


Not to mention
https://www.theguardian.com/society/2014...rainforest
Berry was banned

And the wasp in Brazil with venom that killed cancer cells but didn't harm regular tissue


I googled both, there is still research being done on both the berry and the diagnosis technique. I'm sure its not all out there since companies want to keep their trade secrets.

Unfortunately, advances take a lot of time...partially due to heavy regulatory burdens..... and partially patent protection/business structure stuff so they ensure a profit.

But, its the best system we have. Certainly beats communism in terms of success.


Berry: https://www.frontiersin.org/articles/10....00106/full
Diagnosis: https://www.24-7pressrelease.com/press-r...of-physics

Seems like the diagnosis thing hit a snag though. There was an austrailian company called fermiscan that went bankrupt
https://raggedtext.wordpress.com/2012/09...as-voyage/

Pretty unfortunate case with how a brilliant scientist but poor businesswoman couldn't get the invention commercialized.

Or maybe her results weren't real since no one could reproduce them?
-->https://pdfslide.net/documents/untangling-a-new-breast-cancer-screening-technology.html

Interesting case....

A man should never be ashamed to own that he is wrong, which is but saying in other words that he is wiser today than he was yesterday.
-Alexander Pope
(This post was last modified: 09-19-2019 12:58 PM by Blake2.)
09-19-2019 12:39 PM
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RE: Alex Trebek and his bout with cancer
Cancer treatment is a business. Chemotherapy and Radiation Treatment are ineffective scams. They may let you cling on longer, in misery, but studies have shown they produce little to no positive effect.

My best friend died of pancreatic cancer a few years ago and I went on a crusade to learn all I could about the condition. I have been planning a datasheet but haven't had the time to write it yet.

Cancer is NOT a genetic disorder initially. Its metabolic. Thomas Seyfried, a biology professor at Boston College, wrote an incredibly interesting book: Cancer as a Metabolic Disease. He wrote about how this was the original idea Otto Warburg, a pre WW2 German biologist, discovered.

TLDR:

Cells can create cellular energy (ATP) via two methods. In the mitochondria (24 times more effective I believe) or via fermentation in the cytoplasm (not efficient and creates lactic acid). This is one reason your muscles are sore after an intense workout... the mitochondria in the muscle cells are overworked and fermentation occurs to supplement.

The mitochondria can combine oxygen with fat, glucose or protein to make ATP.

ALL cancer cells have destroyed mitochondria and can only create energy via fermentation. Fermentation requires glucose and cannot use fat or protein.

Extra TLDR: If you have cancer don't ingest any type of sugar. It may not cure you but you'll be starving out cancer cells. The first thing they did when my buddy got to the hospital was put him on a glucose drip and he deteriorated immediately. But what the fuck who cares... you can't make money on changing the patients diet.

This man is the most red pilled man in biology:




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(This post was last modified: 09-19-2019 01:20 PM by RIslander.)
09-19-2019 01:09 PM
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RE: Alex Trebek and his bout with cancer
Great info RIslander.
I've read up over the years on cancer. That Seyfried book is expensive even on amazon. Adding it to the printout I carry to my usual book haunts where I comb for books.

My parents are of the type of boomer that never exercises, eats like crap and expects a Dr. to magically fix things when their health, assuredly, goes wrong.
I don't know if it's me being callous or uncaring of their eventual bad health predicaments but they've got to know that their body will suffer at some point.
The sugar aspect of cancer is very interesting and I await the datasheet, patiently, as I know it's very time intensive to compile something so thorough and data heavy.

Thanks, RIslander.

I doubt it. Remember that your lower level, millenial leftist isn't good at critical thinking. They're largely like trained dogs who emote in response to programmed cues like the word "racism" and "socialism". Easy_C

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09-19-2019 05:14 PM
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SeaFM Offline
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RE: Alex Trebek and his bout with cancer
I was surprised when they were doing the victory lap a few weeks ago.

Finishing chemo is nice, but it’s one step of treatment.

Sad to hear the news, but not surprised.
09-19-2019 06:47 PM
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RE: Alex Trebek and his bout with cancer
(09-19-2019 01:09 PM)RIslander Wrote:  Chemotherapy and Radiation Treatment are ineffective scams. They may let you cling on longer, in misery, but studies have shown they produce little to no positive effect.

I'm sad you believe this falsehood.

I didn't quote your first sentence but your lead betrays you. Of course, any service in an even quasi capitalistic environment can be a business. What isn't a "business"? People even refer to religions as businesses. You see what you want to see.

If Chemo and Radiation are "ineffective" and "scams" then why do people get cured? Why does the US have far better 5 year survival for nearly every cancer than in Europe? We spend a lot of money curing and making people live longer. Any debate on the worthwhile nature of that is a different issue.

Yes, pediatric cancers are "metabolic". Yeah, the 30 year-olds that got lymphoma and get cured had "metabolic" diseases. Come on man, you don't even know what a metabolic disease is. You just can't face up to the fact that life is how it is, and we have to die from something.

You need someone to tell you that you have been deceived.

I am that man.
(This post was last modified: 09-19-2019 07:34 PM by Kid Twist.)
09-19-2019 07:32 PM
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RE: Alex Trebek and his bout with cancer
(09-19-2019 05:14 PM)estraudi Wrote:  My parents are of the type of boomer that never exercises, eats like crap and expects a Dr. to magically fix things when their health, assuredly, goes wrong.

Yes, and somehow the medical system does. Think of it, your parents have and will live longer than 90% of the people that ever lived on the planet.

And at the same time, medicine is a "business" and a "scam".

Sign me up for that scam, man! I'll take one to go, too!
09-19-2019 07:37 PM
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RE: Alex Trebek and his bout with cancer
Thanks for posting those links Blake2!

I had seen very small mention of it in the passing years.... figured either someone bought it up and buried it or something else
If anyone is interested in the inventor video where it was featured PM me and I will upload it

Brazilian wasp (I honestly believe there is probably a cure for everything in the amazon....if they have the worst most poisoness spider that gives you erections and fish that swim up your dick who knows what else they have)
https://www.bbc.com/news/health-34115112


I was talking to a woman not long ago that mentioned a centre in Phoenix that treated cancer with scorpion venom too.... doing searches on this brings up a lot more recent activity .... def hit google for this one

https://www.cbsnews.com/amp/news/on-the-...mor-paint/

Was interesting that drummer from
poison had a bunch of chemo done and ended up immunotherapy cured him.
https://people.com/celebrity/poison-drum...-free/amp/


This was always a strange one I remember too.... I know this one is reaching but who knows
https://idioteq.com/testaments-chuck-bil...ancer/amp/
(This post was last modified: 09-19-2019 08:24 PM by hedonist.)
09-19-2019 08:23 PM
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SeaFM Offline
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Post: #23
RE: Alex Trebek and his bout with cancer
(09-19-2019 08:23 PM)hedonist Wrote:  This was always a strange one I remember too.... I know this one is reaching but who knows
https://idioteq.com/testaments-chuck-bil...ancer/amp/

Doesn’t seem like this guy ever had cancer.
09-19-2019 09:41 PM
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etwsake Offline
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Post: #24
RE: Alex Trebek and his bout with cancer
It's always unpleasant whenever a famous person gets cancer, even if you're not a fan. Cause basically you are passively watching this person die in slow motion.

Every time I see the name "Alex Trebek" I immediately think "Oh, did he die today?"

Cancer is horrible enough, but being under a microscope for the entire world while you're dying makes it so much more gruesome.
09-20-2019 04:12 AM
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Blake2 Offline
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Post: #25
RE: Alex Trebek and his bout with cancer
(09-19-2019 07:37 PM)Kid Twist Wrote:  
(09-19-2019 05:14 PM)estraudi Wrote:  My parents are of the type of boomer that never exercises, eats like crap and expects a Dr. to magically fix things when their health, assuredly, goes wrong.

Yes, and somehow the medical system does. Think of it, your parents have and will live longer than 90% of the people that ever lived on the planet.

And at the same time, medicine is a "business" and a "scam".

Sign me up for that scam, man! I'll take one to go, too!


While definitely there is a benefit to medicine, the best case is to never get sick in the first place (diet, exercise, stress control, avoid drug addiction/HIV/etc)

The fact that avg. life expectancy in the US has gone DOWN in the past few years shows that there is something wrong with people's health these days.

A man should never be ashamed to own that he is wrong, which is but saying in other words that he is wiser today than he was yesterday.
-Alexander Pope
(This post was last modified: 09-20-2019 05:44 AM by Blake2.)
09-20-2019 05:43 AM
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