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Anti-Aging Datasheet: How To Look Younger Than Your Real Age
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<blockquote data-quote="Johnnyvee" data-source="post: 1005789" data-attributes="member: 13195"><p>Just a quick note on collagen supplements and protein in general. I`m a big fan of collagen hydrolysate also, and have used the Great lakes brand for years already. Collagen production is reduced already from age 20-25, so it`s well worth taking. It should be mentioned however that when various fibroblasts/stromal cells synthesize collagen fibers, vitamin C is depleted. So it`s vital to have a high vit. C diet also. That would be things like red and yellow bell peppers, green veg, lemons and limes and so on. </p><p></p><p>What is really important to know though, is that when your eat or supplement your diet with any type of protein/amino acids, whether meat, fish, whey, BCAA, collagen/gelatin etc. The effects you will see are all due to increased cell proliferation. This works via the mTor pathway, which has a mitogenic effect on cells. Simply put, when you eat protein or carbs (not so much fat) you will elevate insulin-IGF1. These hormones bind to receptors on cells, that in turn will increase the expression of mTor. This has the effect of increasing the rate of cell division and importantly, suppressing certain repair and maintenance mechanisms in cells, via something called the DAF-16-FOXO pathway. </p><p></p><p>This is an ancient evolved mechanism that basically decide the fate of cells. More food in the environment and the cells will prioritize cell division. In the opposite case, the cells divide less (Telomere sparing) and upregulate repair mechanisms like autophagy. This in order to survive until there is a more food in the environment. This is also how all fasting regimens work, from IF to caloric restriction. <strong>Take mTor lower and you will extend life.</strong> However if you take mTor expression too low, like can happen with extreme ketogenic diets over time, you run into the problem of not enough cell division/differentiation. This is a problem sometimes with keto diets for refractory epilepsy. If the cells don`t divide enough you will see issues like stunted growth, osteopenia, reduced immune function, low libido etc. </p><p></p><p>So what`s the overarching point here? Well, as I mentioned, both carbs and protein will elevate mTor. But protein is (unlike carbs) essential. And also have the positive effects of muscle growth and connective tissue maintenance we`re after. You don`t need glucose for energy however. Fat oxidation is probably better for most. Protein is also a (too) small part of the diet of the average human. About 14 percent in Western Nations. (There`s good data on that in fact.) The big shift recently has really been in the intake of carbs, replacing what was a higher fat diet. This is the main cause of the obesity and chronic disease epidemic we currently see in the West. But in the context of what we`re talking about here, it`s important to be aware of all this. Even if you already have a higher fat Paleo/Low carb type diet. </p><p></p><p>So in order to get the best health outcome you should keep your diet and protein intake <strong>pulsative.</strong> By that I mean that you have long periods between protein (and food) intake from all sources including whey, BCAA, and even collagen. You should have a pretty high protein diet, in fact protein intake is probably to low currently. This is related to satiety also. When you`re lacking in essential nutrients, and especially amino acids, you will seek out more food until you`re satisfied. The problem with for example the standard American diet, is that you have to eat something like 30.000 calories a day to get those essential nutrients. This partly explains why people continue eating non stop. </p><p></p><p>Anyway, to finish up this rant. Just remember that when you do stuff like Eggs, meat, Whey and Collagen etc, try to consume them together or within in a short time span. Then wait a long time for your next meal. You can eat as much as you feel like, as long as you space out your meals in this fashion. 2 meals a day would be the best, but a post workout meal including protein supplements on training days is acceptable. And of course non of this matters if you have a high carb diet. So a Paleo type approach, including meat, organ meats, fish, eggs, nuts, seeds, herbs and spices, and lots of low to medium GL veg would be the best.</p></blockquote><p></p>
[QUOTE="Johnnyvee, post: 1005789, member: 13195"] Just a quick note on collagen supplements and protein in general. I`m a big fan of collagen hydrolysate also, and have used the Great lakes brand for years already. Collagen production is reduced already from age 20-25, so it`s well worth taking. It should be mentioned however that when various fibroblasts/stromal cells synthesize collagen fibers, vitamin C is depleted. So it`s vital to have a high vit. C diet also. That would be things like red and yellow bell peppers, green veg, lemons and limes and so on. What is really important to know though, is that when your eat or supplement your diet with any type of protein/amino acids, whether meat, fish, whey, BCAA, collagen/gelatin etc. The effects you will see are all due to increased cell proliferation. This works via the mTor pathway, which has a mitogenic effect on cells. Simply put, when you eat protein or carbs (not so much fat) you will elevate insulin-IGF1. These hormones bind to receptors on cells, that in turn will increase the expression of mTor. This has the effect of increasing the rate of cell division and importantly, suppressing certain repair and maintenance mechanisms in cells, via something called the DAF-16-FOXO pathway. This is an ancient evolved mechanism that basically decide the fate of cells. More food in the environment and the cells will prioritize cell division. In the opposite case, the cells divide less (Telomere sparing) and upregulate repair mechanisms like autophagy. This in order to survive until there is a more food in the environment. This is also how all fasting regimens work, from IF to caloric restriction. [b]Take mTor lower and you will extend life.[/b] However if you take mTor expression too low, like can happen with extreme ketogenic diets over time, you run into the problem of not enough cell division/differentiation. This is a problem sometimes with keto diets for refractory epilepsy. If the cells don`t divide enough you will see issues like stunted growth, osteopenia, reduced immune function, low libido etc. So what`s the overarching point here? Well, as I mentioned, both carbs and protein will elevate mTor. But protein is (unlike carbs) essential. And also have the positive effects of muscle growth and connective tissue maintenance we`re after. You don`t need glucose for energy however. Fat oxidation is probably better for most. Protein is also a (too) small part of the diet of the average human. About 14 percent in Western Nations. (There`s good data on that in fact.) The big shift recently has really been in the intake of carbs, replacing what was a higher fat diet. This is the main cause of the obesity and chronic disease epidemic we currently see in the West. But in the context of what we`re talking about here, it`s important to be aware of all this. Even if you already have a higher fat Paleo/Low carb type diet. So in order to get the best health outcome you should keep your diet and protein intake [b]pulsative.[/b] By that I mean that you have long periods between protein (and food) intake from all sources including whey, BCAA, and even collagen. You should have a pretty high protein diet, in fact protein intake is probably to low currently. This is related to satiety also. When you`re lacking in essential nutrients, and especially amino acids, you will seek out more food until you`re satisfied. The problem with for example the standard American diet, is that you have to eat something like 30.000 calories a day to get those essential nutrients. This partly explains why people continue eating non stop. Anyway, to finish up this rant. Just remember that when you do stuff like Eggs, meat, Whey and Collagen etc, try to consume them together or within in a short time span. Then wait a long time for your next meal. You can eat as much as you feel like, as long as you space out your meals in this fashion. 2 meals a day would be the best, but a post workout meal including protein supplements on training days is acceptable. And of course non of this matters if you have a high carb diet. So a Paleo type approach, including meat, organ meats, fish, eggs, nuts, seeds, herbs and spices, and lots of low to medium GL veg would be the best. [/QUOTE]
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