In the largest study of its kind to date, researchers at Massachusetts General Hospital (MGH), Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard have found the new mRNA COVID-19 vaccines to be highly effective in producing antibodies against the SARS-CoV-2 virus in pregnant and lactating women. The study also demonstrated the vaccines confer protective immunity to newborns through breast milk and the placenta.
The study, published in the American Journal of Obstetrics and Gynecology (AJOG), looked at 131 women of reproductive age (84 pregnant, 31 lactating and 16 non-pregnant), all of whom received one of the two new mRNA vaccines: Pfizer/BioNTech or Moderna. The vaccine-induced titers — or antibody levels — were equivalent in all three groups. Reassuringly, side effects after vaccination were rare and comparable across the study participants.
“This news of excellent vaccine efficacy is very encouraging for pregnant and breastfeeding women, who were left out of the initial COVID-19 vaccine trials,” said Andrea Edlow, a maternal-fetal medicine specialist at MGH, director of the Edlow Lab in the Vincent Center for Reproductive Biology and co-senior author of the new study. “Filling in the information gaps with real data is key — especially for our pregnant patients who are at greater risk for complications from COVID-19. This study also highlights how eager pregnant and lactating individuals are to participate in research.”
According to the Centers for Disease Control and Prevention, individuals who are pregnant are more likely to become severely ill with COVID-19, require hospitalization, intensive care or ventilation — and may be at increased risk for adverse pregnancy outcomes. The team also compared vaccination-induced antibody levels to those induced by natural infection with COVID-19 in pregnancy, and found significantly higher levels of antibodies from vaccination.
Vaccine-generated antibodies were also present in all umbilical cord blood and breast milk samples taken from the study, showing the transfer of antibodies from mothers to newborns.
“We now have clear evidence the COVID vaccines can induce immunity that will protect infants,” said Galit Alter, core member of the Ragon Institute and co-senior author of the study. “We hope this study will catalyze vaccine developers to recognize the importance of studying pregnant and lactating individuals, and include them in trials. The potential for rational vaccine design to drive improved outcomes for mothers and infants is limitless, but developers must realize that pregnancy is a distinct immunological state, where two lives can be saved simultaneously with a powerful vaccine. We look forward to studying all vaccine platforms in pregnancy as they become available.”
The study was also able to provide insight into potential differences between the immune response elicited by the Pfizer vaccine compared to the Moderna vaccine, finding the levels of mucosal (IgA) antibodies were higher after the second dose of Moderna compared to the second dose of Pfizer.
“This finding is important for all individuals, since SARS-CoV-2 is acquired through mucosal surfaces like the nose, mouth and eyes,” said Kathryn Gray, an obstetrician at Brigham and Women’s Hospital and a first author of the paper. “But it also holds special importance for pregnant and lactating women because IgA is a key antibody present in breast milk.”
Gray’s co-first authors on the study are Evan Bordt of MGH and Caroline Atyeo of the Ragon Institute.
Funding for the study included grants from the National Institute of Child Health and Human Development (NICHD), the Gates Foundation, the Massachusetts Consortium on Pathogen Readiness (MassCPR) and the Musk Foundation.
Edit. Examples of "Roll Up Your Sleeve" campaign.
Governor Cuomo Announces "Roll Up Your Sleeve" Campaign to Encourage Houses of Worship of All Faiths to Sign Up as Vaccination SitesGovernor Cuomo announced the launch of the "Roll Up Your Sleeve" Campaign to promote houses of worship of all faiths across the state to sign up as vaccination sites for their communities.www.governor.ny.gov
I really thought they were done with old pathetic "bodies on the street, no one to cleanup" tale (always used in remote countries with closed borders so one can't check). But yes, here they're at it again. It's not even funny anymore. I guess India didn't rush into their globo-centralization system fast enough and needs to speed up on vaxx pass QR codes to leave the house.The media has lost any dignity, any restraint, any morality. They're doing the same for Brazil now as they want to get Bolsonaro out obviously
Brazilian President Jair Bolsonaro has suggested that the army might be called into the streets to restore order if lockdown measures against COVID-19 that he opposes lead to chaos.
In a television interview Friday night with TV Criticia in the Amazon city of Manaus, Bolsonaro repeated his frequent criticism of restrictions imposed by local governments to curb infections — measures he claims do more harm than good.
“That lockdown policy, of quarantine, is absurd. If we have problems ... we have a plan of how to act. I am the supreme head of the armed forces,” Bolsonaro said.
He said the army could be summoned to “reestablish Article 5 of the Constitution,” which mentions the right to freedoms of movement and of religion.
Bolsonaro also said the restrictive measures are aggravating hunger in the country.
“I am, together with my 23 ministers, talking about what to do if a generalized chaos is implanted in Brazil because of hunger, because of the cowardly way of how some are making the people stay at home,” he added.
BasedBolsanaro in Brazil said he's ready to call army onto the streets, because of lockdown pushers, whom he can't control, imposing lockdowns to deliberately destroy Brazil.
RIO DE JANEIRO (AP) — Brazilian President Jair Bolsonaro has suggested that the army might be called into the streets to restore order if lockdown measures against COVID-19 that he opposes lead to chaos. In a television interview Friday night with TV Criticia in the Amazon city of Manaus...apnews.com
The U.S. is slowly ramping up its commitments to help India, which has been consistently reporting more than 300,000 new daily coronavirus cases. But as the world's second most populous country — with more than 1.4 billion people — some experts say the response is too slow.
"There is a humanitarian reason to do this, as well as self-interest, to prevent new variants from arriving," Dr. Leana Wen, former Baltimore health commissioner and a visiting professor at the Milken Institute School of Public Health at George Washington University, told Yahoo Finance.
Prior to the surge, India was boasting faster vaccination rates than the U.S. and had donated doses to neighboring countries in need. India has since shifted to prioritize its citizens first, contributing to a slowdown in vaccinations in Europe and elsewhere.
The Serum Institute of India (SII) is Oxford University/AstraZeneca's (AZN) partner to produce billions of doses of vaccines for a majority of the world. But as the home of SII, the world's largest vaccine producer, the Indian government exercised pressure on the company to pivot to domestic distribution.
The U.S. has also been focused on inoculating its own population before committing to global distribution. But as vaccine supplies now outstrip demand, the Biden administration announced it will send up to 60 million doses to countries around the world, but only after regulatory review. Experts estimate that could mean doses will reach them by the end of May.
The nation of 1.3 billion people recorded 352,991 new infections and 2,812 deaths on Monday, its highest levels since the pandemic began
Australia on Tuesday announced a temporary ban on direct passenger flights from India, as the South Asian nation grapples with a massive surge in coronavirus infections.
Prime Minister Scott Morrison said the suspension would remain in place until at least May 15 due to "clearly present" risks of travel from India, leaving thousands of Australians -- including high-profile cricketers -- stranded.
It follows similar moves by countries including Canada, the United Arab Emirates and Britain to halt or restrict flights in response to the spiralling Covid crisis.
Morrison also said Australia would send medical aid, including oxygen tanks, ventilators and personal protective equipment, to India as its health system strains under the growing caseload.
In reference to India's devastating second wave of the pandemic, UK Prime Minister Boris Johnson's spokesperson said the process is kept under constant review, while the country sends an assistance package made up of 495 oxygen concentrators, 120 non-invasive ventilators and 20 manual ventilators to India to meet the supply shortages over the course of the week
The UK is currently moving through its domestic priority lists for COVID-19 vaccines and therefore, has no surplus doses to share with countries in need such as India at this stage, Downing Street said on Tuesday.
In reference to India's devastating second wave of the pandemic, UK Prime Minister Boris Johnson's spokesperson said the process is kept under constant review, while the country sends an assistance package made up of 495 oxygen concentrators, 120 non-invasive ventilators and 20 manual ventilators to India to meet the supply shortages over the course of the week.
The first tranche of 100 ventilators and 95 oxygen concentrators arrived in New Delhi early on Tuesday.
"We committed in February to sending excess doses from the UK's supply to the COVAX procurement pool and to countries in need, once they are available," the UK PM's spokesperson said.
"Right now, we are moving through the UK prioritisation list for our domestic rollout and don't have surplus doses, but we keep this under constant review. We recognise that no one is safe until we're all safe in this pandemic which is why the UK has contributed GBP 548 million to COVAX and sent vital medical supplies to India," the spokesperson said.
The COVAX facility refers to the COVID-19 Vaccines Global Access global initiative aimed at equitable access to vaccines led by Gavi, the Vaccine Alliance, the Coalition for Epidemic Preparedness Innovations (CEPI), and the World Health Organisation (WHO).
The latest update from Downing Street comes as it emerged that the US is to export around 60 million doses of the Oxford/AstraZeneca vaccine, with India expected to be among the biggest recipients of the consignment after talks between US President Joe Biden and Prime Minister Narendra Modi.
With 3,23,144 people testing positive for the coronavirus in a day, India's infection tally climbed to 1,76,36,307 on Tuesday. The death toll mounted to 1,97,894 with 2,771 new fatalities.
Several efforts are on within the Indian diaspora in the UK to fundraise for essential supplies, such as oxygen concentrators and coordinate distribution of across India's struggling hospitals through a series of emergency appeals, including by charities such as the British Asian Trust and British Association of Physicians of Indian Origin (BAPIO).
I get called crazier every day. Stay strong brothersMore India's "COVID Pandemic" propaganda B.S.
The U.S. is slowly ramping up its commitments to help India, which has been consistently reporting more than 300,000 new daily coronavirus cases. But as the world's second most populous country — with more than 1.4 billion people — some experts say the response is too slow.finance.yahoo.com
Australia on Tuesday announced a temporary ban on direct passenger flights from India, as the South Asian nation grapples with a massive surge in coronavirus infections. Prime Minister Scott Morrison said the suspension would remain in place until at least May 15 due to "clearly present" risks...www.wionews.com
The UK is currently moving through its domestic priority lists for COVID-19 vaccines and therefore, has no surplus doses to share with countries in need such as India at this stage, Downing Street said on Tuesday. In reference to India's devastating second wave of the pandemic, UK Prime...www.wionews.com