I am not a M.D., but have credentials in the natural sciences.
So to present my current understanding of the topic of COVID vs. Vitamin C.
I read up on cytokine storms:
From German wikipedia site.
https://de.wikipedia.org/wiki/Zytokinsturm
Bei einem Zytokinsturm werden hohe Konzentrationen der Zytokine IL-6 und IL-8 sowie der Chemokine CCL2, CCL5, CXCL10 und CXCL9 gebildet.[3]
During a cytokine storm high concentrations of "Zytokine IL-6 und IL-8 sowie der Chemokine CCL2, CCL5, CXCL10 und CXCL9 " are produced. [in positive self enforcing feedback loop].
Symptoms:
Fieber, Übelkeit, Schüttelfrost, Arterielle Hypotonie, Tachykardie, Asthenie, Kopfschmerz, Exanthem und Dyspnoe.
Fever, Nausea, cold chills (shaking), hypotension?, tachycardia, general weakness, headache, exanthem, short breath.
From English wikipedia:
https://en.wikipedia.org/wiki/Cytokine_release_syndrome
This basically describes the critical progress of COVID-19.
Grades Toxicity
Grade 1 Mild reaction, infusion interruption not indicated; intervention not indicated
Grade 2 Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs
Grade 3 Prolonged (e.g., not rapidly responsive to symptomatic medication or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates)
Grade 4 Life-threatening consequences;
pressor or ventilatory support indicated
Grade 5 Death
It's not the virus killing you, it's your immune system overreaction which leads to lung inflammation.
How does Vitamin C, work?
https://www.ncbi.nlm.nih.gov/pubmed/15271375
It inhibits some of the cytokine production or down regulates it, so some cells of your immune system are inhibited.
(or it helps to regulate down to a healthy level)
In that case, that may be the reason the saturation limit of Vitamin C increases depending on the level of inflammation/alert status in your body.
The question is, if it makes sense to take Vitamin C megadoses early on, which could? prevent proper immune response to the virus or wait until you get cold chills and fever, then start supplementing if the fever doesn't go down.
My personal conclusions:
In general, I think the Vitamin C mega doses are mainly to combat immune system overreaction. Regular moderate Vitamin C supplementation in the next weeks should be the base for a healthy immune system response.
The effects of Vitamin C supplementation to children seems to be actually reversed regarding specific cytokine production.
https://www.ncbi.nlm.nih.gov/pubmed/17344653