Ivermectin Thread

STG

Woodpecker
The discovery of Ivermectin is actually a fascinating story. Ivermectin comes from a golf course in Japan. As far as I know its never been found anywhere else in nature.

Discovery of Ivermectin

In the late 1960s and early 1970s, Satoshi Ōmura (*1935), a microbiologist and bioorganic chemist at Tokyo’s Kitasato Institute, hunted for new sources of pharmaceuticals. He knew that some existing drugs, including antibiotics, had been derived from compounds found in nature. So he developed screening methods to identify medicinally promising compounds from soil. His team collected thousands of soil samples from around Japan, cultured bacteria from them, and screened each culture for medicinal potential.

In 1971, Ōmura took a sabbatical in the laboratory of Max Tishler (1906–1989), an eminent professor of chemistry at Wesleyan University in the U.S. A year earlier, Tishler had retired from an illustrious research career at the pharmaceutical company Merck. Before returning to Japan in 1973, Ōmura arranged a pioneering agreement between the company and the research institute. Kitasato would continue to collect samples and screen them, and then send the most promising ones to Merck Research Laboratories in Rahway, New Jersey, for testing and development. The institute would receive royalties from any products that were commercialized through the partnership. At Merck Research Labs, a team led by parasitology specialist William Campbell (*1930) began testing the samples as potential treatments for parasitic worms. A veterinary scientist and zoologist by training, Campbell identified compounds that could be effectively developed as drugs for livestock and other animals. To test potential treatments, the Merck researchers first infected mice with nematodes and then fed each mouse a different culture sample supplied by Ōmura’s team. They found that one culture was extraordinarily effective at ridding mice of worm infestations.

This culture was derived from soil collected near a golf course in Kawana, about 80 miles southwest of Tokyo. Ōmura identified the bacterium in that culture as a new strain, which was ultimately christened Streptomyces avermectinius. The Merck team isolated the active component produced by the bacterium and named it “avermectin.” They found that avermectin is actually a combination of eight closely related compounds. The researchers began chemically modifying the compounds, tweaking their molecular structures slightly to see if they could make avermectin even more potent against parasites and safer for the animals being treated. By synthesizing thousands of similar compounds, Merck scientists found that, with slight chemical modification, some of the avermectin compounds displayed enhanced activity as well as safety. They dubbed the resulting pair of avermectin derivatives “ivermectin.” The mixture was 25 times more potent than existing treatments for parasitic worms. Further testing at Merck showed that ivermectin could also fight infestations by mites, ticks and botfly parasites that cause huge economic losses in the livestock industry. It was effective against parasites in horses, cattle, pigs, sheep and dogs, and was largely nontoxic to these animals. These gratifying results led Merck to commercialize ivermectin as a veterinary treatment beginning in 1981. Starting in 1987, the drug was also marketed to the public under the brand name Heartgard® (now sold by the animal-health company Merial) to prevent heartworms in dogs. These products quickly became the top-selling veterinary medicines in the world, with sales topping $1 billion annually
 

STG

Woodpecker
Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

There are few drugs that can seriously lay claim to the title of ‘Wonder drug’, penicillin and aspirin being two that have perhaps had greatest beneficial impact on the health and wellbeing of Mankind. But ivermectin can also be considered alongside those worthy contenders, based on its versatility, safety and the beneficial impact that it has had, and continues to have, worldwide—especially on hundreds of millions of the world’s poorest people. Several extensive reports, including reviews authored by us, have been published detailing the events behind the discovery, development and commercialization of the avermectins and ivermectin (22,23-dihydroavermectin B), as well as the donation of ivermectin and its use in combating Onchocerciasis and lymphatic filariasis.16) However, none have concentrated in detail on the interacting sequence of events involved in the passage of the drug into human use.

When it first appeared in the late-1970s, ivermectin, a derivative of avermectin (Fig. (Fig.1 )1 ) was a truly revolutionary drug, unprecedented in many ways. It was the world’s first endectocide, forerunner of a completely new class of antiparasitic agents, potently active against a wide range of internal and external nematodes and arthropods. In the early-1970s, a novel international Public Sector–Private Sector partnership was initiated by one of us (Ōmura, then head of the Antibiotics Research Group at Tokyo’s Kitasato Institute), forming a collaboration with the US-based Merck, Sharp and Dohme (MSD) pharmaceutical company. Under the terms of the research agreement, researchers at the Kitasato Institute isolated organisms from soil samples and carried out preliminary in vitro evaluation of their bioactivity. Promising bioactive samples were then sent to the MSD laboratories for further in vivo testing where a potent and promising novel bioactivity was found, subsequently identified as being caused by a new compound, which was named ‘avermectin’.7) Despite decades of searching around the world, the Japanese microorganism remains the only source of avermectin ever found.1) Originating from a single Japanese soil sample and the outcome of the innovative, international collaborative research partnership to find new antiparasitics, the extremely safe and more effective avermectin derivative, ivermectin, was initially introduced as a commercial product for Animal Health in 1981. It is effective against a wide range of parasites, including gastrointestinal roundworms, lungworms, mites, lice and hornflies.712) Ivermectin is also highly effective against ticks, for example, the ixodid tick Rhipicephalus (Boophilus) microplus, one of the most important cattle parasites in the tropics and subtropics, which causes enormous economic damage. Indicative of the impact, in Brazil, where some 80% of the bovine herd is infested, losses total about $2 billion annually.13) Today, ivermectin is being used to treat billions of livestock and pets around the world, helping to boost production of food and leather products, as well as keep billions of companion animals, particularly dogs and horses, healthy. The ‘Blockbuster’ drug in the Animal Health sector, meaning that it achieved annual sales in excess of over US$1 billion, maintained that status for over 20 years. It is so useful and adaptable that it is also being used off-label, sometimes, illegally, for example to treat fish lice in the aquaculture industry, where it can have a negative impact on non-target organisms. It also has extensive uses in agriculture.2)
 

STG

Woodpecker
Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight Onchocerciasis.57)

Today, ivermectin is being increasingly used worldwide to combat other diseases in humans, such as Strongyloidiasis (which infects some 35 million each year), scabies (which causes 300 million cases annually), Pediculosis, Gnathostomiasis and Myiasis—and new and promising properties and uses for ivermectin and other avermectin derivatives are continuing to be found.58) These include activity against another neglected tropical disease, Leishmaniasis.59,60) Of perhaps even greater significance is the evidence that the use of ivermectin has both direct and indirect beneficial impact on improving community health. Studies of long-term treatment with ivermectin to control Onchocerciasis have shown that use of the drug is additionally associated with significant reduction in the prevalence of infection with any soil-transmitted helminth parasites (including Ascaris, Trichuris and hookworm), most or all of which are deemed to be major causes of the morbidity arising from poor childhood nutrition and growth.61) It is also known that the prevalence of head lice is markedly reduced in children taking ivermectin tablets62) and that scabies is markedly reduced in populations taking the drug regularly.63) Above all, ivermectin has proved to be a medicine of choice for the world’s rural poor. In many underprivileged communities throughout the tropics, intestinal worms and parasitic skin diseases are extremely common and associated with significant morbidity. They usually co-exist, with many individuals infected with both ecto- and endoparasites.64,65) Mass treatment of poly-parasitized populations is deemed to be the best means of control and ivermectin is the ideal drug for such interventions. A recent study in Brazil, using locally produced ivermectin, looked at the impact on internal helminthes and parasitic skin diseases. The researchers concluded that “mass treatment with ivermectin was an effective and safe means of reducing the prevalence of most of the parasitic diseases prevalent in a poor community in North-East Brazil. The effects of treatment lasted for a prolonged period of time”. This study also represented the first published report of human medical intervention using ivermectin that had not been produced by the hitherto traditional manufacturer, Merck & Co. Inc., the patent on the drug expiring in 1997.66)
 

get2choppaaa

Ostrich
Before I ask what's with the name of your profile, you seem to have a somewhat anti Ivermectin stance from what I have seen. Since I am trying to consider the source here, why should Dr Kaufman's commentary be taken over that of Dr. Zev Zelenko whose protocol calls for HCQ/IVM/+Zinc or EGCG or ZPAK ect...

What risks are you suggesting there are with IVM? The standard dose is like 12-15mg per day. the LD50 in humans is something like 15mg per kg (a 200 lb man or 91 kg... would need to take 90X the standard dose or 1365 mg or 113 pills. aside from the fact that that is obviously retarded and handful++ of pills, its roughly $450 of medicine in one dose assuming somewhere between $3-$5 a pill.

SOOOO what harm is there in that?

Its use prophylacticly is between 3mg-18mgs as others on here can attest... so I am not sure what the concern is except if you are saying there isnt a need to take drugs just to take them (which I would agree with)



3 biggest medical discoveries over the last 100 years are:
Aspirin
Penicillin
Ivermectin
 
Before I ask what's with the name of your profile, you seem to have a somewhat anti Ivermectin stance from what I have seen. Since I am trying to consider the source here, why should Dr Kaufman's commentary be taken over that of Dr. Zev Zelenko whose protocol calls for HCQ/IVM/+Zinc or EGCG or ZPAK ect...

What risks are you suggesting there are with IVM? The standard dose is like 12-15mg per day. the LD50 in humans is something like 15mg per kg (a 200 lb man or 91 kg... would need to take 90X the standard dose or 1365 mg or 113 pills. aside from the fact that that is obviously retarded and handful++ of pills, its roughly $450 of medicine in one dose assuming somewhere between $3-$5 a pill.

SOOOO what harm is there in that?

Its use prophylacticly is between 3mg-18mgs as others on here can attest... so I am not sure what the concern is except if you are saying there isnt a need to take drugs just to take them (which I would agree with)



3 biggest medical discoveries over the last 100 years are:
Aspirin
Penicillin
Ivermec

My username is an inside joke. Watch the video yourself. In short besides anecdotal evidence, the scientific evidence for ivermectin curing Covid is wish-washy, and while it may help short term symptoms, it does not solve the long term cause for why someone gets sick in the first place.
 

get2choppaaa

Ostrich
My username is an inside joke. Watch the video yourself. In short besides anecdotal evidence, the scientific evidence for ivermectin curing Covid is wish-washy, and while it may help short term symptoms, it does not solve the long term cause for why someone gets sick in the first place.
Got it.

I don't agree about the sceintific evidence being wishy-washy... there is a lot of solid data showing that it works, as well as annecdotal experience showing it works (from many among here on the board)

I watched the video.

He recommends turpentine and enemas.

He didn't sound extreme in his commentary and said that IVM probably works on people with bacterial infections in the lungs due to worms ect...

That notwithstanding, I didnt see how ANYTHING he said showed a reason NOT to take IVM in case of sicknes or prophylacticly.

If I get sick, which I doubt will happen based off of the robust immune system and multiple previous exposures, I will be taking the HCQ and IVM treatment with some zinc lossanges, along with my standard Vitamin D, NAC, Choline/Inositol/L-methionine, EGCG, and fish oil.
 

Easy_C

Peacock
My username is an inside joke. Watch the video yourself. In short besides anecdotal evidence, the scientific evidence for ivermectin curing Covid is wish-washy, and while it may help short term symptoms, it does not solve the long term cause for why someone gets sick in the first place.
I wouldn't think it would address the "getting infected" part. That said the ability to keep short term symptoms out of hand is the difference between something that's a nuisance or something that's a genuine pandemic.
 

lskdfjldsf

Pelican
Orthodox Catechumen
Gold Member
Mine came in as well (horse paste).

I am nervous about measuring the correct dosage. 1/6 of the tube every 48 hours seems to be the concensus. I can't find any good info on this.
 

Eusebius Erasmus

Pelican
Orthodox
My username is an inside joke. Watch the video yourself. In short besides anecdotal evidence, the scientific evidence for ivermectin curing Covid is wish-washy, and while it may help short term symptoms, it does not solve the long term cause for why someone gets sick in the first place.
The peer-reviewed scientific evidence for Ivermectin is undoubtable:



You can push the claim that Ivermectin doesn't work against Covid-19, but then you're running against mountains of evidence.
 

STG

Woodpecker
Merck's patent on Ivermectin expired in 1997.

Their new anti viral pill is probably different enough from Ivermectin to call it something else but is really just rebranded Ivermectin.
 

nagareboshi

Woodpecker
Please pray for my mother Amy. I thought we did everything right and now she is deteriorating in the hospital. Please please pray for her. Her oxygen levels are very low and the doctors said there’s not much more they can do. She has been sick for two weeks now. I keep praying and asking God and He didn’t tell me why. This is the first time God was silent on me for such a major issue. I’m very scared.
 
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