For once, Florida isn't the worst state...
Brazil Donkey Kong wind up punch releasing, 21k new cases today by far all time high and surpassing U.S. for most daily cases today. U.S. worst day was 30k cases. They will likely be second in world for total cases on their way to #1 starting tomorrow. Sao Paulo I guess announced a 5 day holiday to get people to stay home that it is that bad. Two health ministers have left the federal gov. one after the other. I don't see numbers slowing down there. I see India maybe faring a bit better, Brazil just seems like a place with much less order in general. Also I've met a lot of Indian doctors and engineers, they will figure something out. From Brazil I've just met guys that like to dance, party, enjoy simple pleasures, not a lot of serious doctor or engineer types.
I keep mentioning them because in ways like China all the Brazilian slums like wet markets and crazy jungle bats like pangolins & panda bears offer room for mutation if they end up having millions of cases which is almost in stone... somewhere like Sweden would not have the same issues if it was overrun.
Imagine if the virus gave women blonde hair and bigger breasts though? Would there be an outcry or world peace?
Does anyone know what second wave means? Does that mean a stronger mutation happens, weather changes, or people congregate more closely? Is second wave just a catch all term for "it spread more later in time for any possible number of reasons combine in a way we don't really know how"?
President Donald Trump on Wednesday said he plans to stop taking hydroxychloroquine “in a day or two.”
Trump took the drug as a way to prevent the disease caused by the coronavirus despite scientist’s concerns.
"I think the regimen finishes in a day or two. I think it's in two days," Trump told reporters during a meeting with the governors of Arkansas and Kansas according to The Hill.
The Food and Drug Administration last month cautioned against the use of the medicine outside of a hospital setting or a clinical trial due to risk of heart rhythm problems, citing potential “life threatening” heart problems.
The president has defended his choice, saying the drug “gives you an additional level of safety” and claimed, “many doctors are in favor of it” and that “many frontline workers won’t go there unless they have hydroxy.”
Trump has also been taking a daily dose of zinc and an initial dose of the antibiotic azithromycin.
Dr. Sean Conley, the president’s physician, has not said whether he’d prescribed the drug to Trump or recommended a dosage.
“After numerous discussions he and I had regarding the evidence for and against the use of hydroxychloroquine,” Conley wrote in a memo released by the White House on Monday, “we concluded the potential benefit from treatment outweighed the relative risks.”
“I continue to monitor the myriad studies investigating potential COVID-19 therapies.”
President Donald Trump on Wednesday said he plans to stop taking hydroxychloroquine "in a day or two." Trump took the drug as a way to prevent the disease caused by the coronavirus despite scientist's concerns....www.newsmax.com
From what I've heard, most governors in Brazil are trying to do lockdowns (to the extent that it's possible in their condition, given the favelas and all that), while Bolsonaro is a "just a flu" guy and fighting them on the federal level. Any truth to this?
...Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases and a key adviser to Mr. Trump on the pandemic, has dismissed any suggestion that the virus came from a Chinese laboratory.
“If you look at the evolution of the virus in bats and what’s out there now, [the scientific evidence] is very, very strongly leaning toward this could not have been artificially or deliberately manipulated,” he told National Geographic this month.
“Everything about the stepwise evolution over time strongly indicates that [this virus] evolved in nature and then jumped species.”
The forthcoming study, however, concludes that the binding energy of the virus’ “spike” protein — the crownlike protrusions surrounding the surface of the round microbe — is highest for humans and greater than all other species tested, including bats, which have been widely targeted as the likely original source.
“This indicates that SARS-CoV-2 is a highly adapted human pathogen,” the Australian report said.
The team analyzed spike protein binding of the virus on a range of other animals, including pangolins, civets, mice, hamsters, cats, dogs, snakes, horses, tigers and cows.
“Overall, the data indicates that SARS-CoV-2 is uniquely adapted to infect humans, raising important questions as to whether it arose in nature by a rare chance event or whether its origins might lie elsewhere,” the report said.
Jonathan J. Couey, a research assistant professor of neurobiology at the University of Pittsburgh, said he agrees with the Australian findings.
“Understanding the exact origin of this virus is vital to ensure that all scientific and medical data are interpreted correctly by policymakers and health care professionals alike,” Mr. Couey said.
However, he said, debate on the laboratory origin of the virus has been stymied by scientists opposed to even considering the possibility.
“Several scientists with obvious conflicts of interest have been permitted to go on the record denying that it would be possible to generate such a virus in a laboratory and stating specifically that the sequence of SARS-CoV-2 would never have been chosen by any ‘gene jockey,’” he said in an email.
“Both of these denials are not genuine scientific rebuttals, but rather semantic pseudo-denials formulated by some of those most closely tied to the funding of these [gain of function] research lines.”
“Gain-of-function research” is laboratory work to increase the ability of pathogens to cause disease. It is carried out to study pandemics and how to respond to them.
Under international law the penalty for Crimes Against Humanity or Genocide is up to 30 years in prison. If I was anyone that could conclusively tie Fauci and /or any of the rest involved in the NC State / John Hopkins / CIA / Wuhan Lab "gain of function" funding and research...Id be seriously scared right nowWith regard to the concerns summarized by Chris Martenson in his Youtube videos about the possibility of a lab origin, a research paper is coming out that gives more weight to his suspicions:
A forthcoming Australian scientific study concludes that the coronavirus causing the global pandemic contains unique properties suggesting it was manipulated in a Chinese laboratory and was not the result of a natural occurrence.m.washingtontimes.com
No, therapy is still individual apart from that. No HCQ from what I’ve seen so far. No Remdesivir either.
As for when to call medical services: I’d say that if you have breathing problems walking between your bed and toilet, or going up a short stair, you need to be evaluated by a doc or nurse; especially having your blood saturation taken. Seen a few cases where people have been sitting in chairs next to their bathrooms at home (so as to minimize movement), due to extreme tiredness and and probable hypoxia. They usually do this for a few days before calling an ambulance, and when they get to us they’re already on several liters of oxygen.
Dr. Anthony Fauci, the nation's top infectious-disease expert, said on Friday that extended lockdowns could cause "irreparable" harm and worse health outcomes.
"We can't stay locked down for such a considerable period of time that you might do irreparable damage and have unintended consequences, including consequences for health," Fauci said in a CNBC interview.
Fauci, the director of the National Institute of Allergy and Infectious Diseases, said the measures were necessary early on to curb the explosive spread of the coronavirus. But he supported states taking cautious steps to restore normality and lift stay-at-home orders.
"Now is the time, depending upon where you are and what your situation is, is to begin seriously looking at reopening the economy, reopening the country to try and get back to some degree of normal," he said.
Research in context
Evidence before this study
We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.
Added value of this study
In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.
Implications of all the available evidence
Here's the source
They aggregated a bunch of data from a bunch of sources without knowing what controls or quality controls were in place at the sources.
This is not science. This is less than worthless and actually malicious propaganda held out as science.
Only partisan publications are picking it up
Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups (chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide), and patients who received none of these treatments formed the control group.