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<blockquote data-quote="I'mWaitingForTheMan" data-source="post: 68308" data-attributes="member: 2972"><p>Choline+Uridine+Fish Oil(Omega</p><p></p><p>This is without a doubt the best natural combination brain booster out, and it has reasonably hard science behind it, as hard as you'll be liking to find as the field of cognitive enhancement is in its absolute infancy.</p><p></p><p><strong>N-3(also known as Omega-3) Fatty acids</strong>, are far and away the most essential ingredient in this triple threat combo. The <strong>Only</strong> two of these fatty acids you want are EPA(Eicosapentaenoic acid) and DHA(Docosahexaenoic acid). What people don't realize is that you need <strong>WAY</strong> more than an extra strength fish oil tablet to get the cognitive benefits, though you may still get the heart/cholesterol benefits from just a recommended serving. You need at least 3 <strong>Grams</strong> of combined EPA/DHA to get the cognitive/mood benefits. <strong>Always</strong> make sure the fish oil you buy states exactly how much EPA/DHA is in each serving, as those are the only two ingredient you are concerned with. Watch out for the serving size, sometimes they say each serving is 2 gel capsules, so do your math accordingly. When purchasing fish oil, shoot for the ones that say they are purified to remove mercury. From what I've read the mercury in fish stays in their meat/protein for the most part, so whatever makes it into the oil is negligible and then purified. This is probably safer than eating 5-6 servings of fish a week regarding mercury intake anyways.</p><p></p><p>Keep in mind, some evidences suggests it is the ratio of n-3 fatty acids to n-6 that garners more neurocognitive improvement. This means you want to try to get more of your fats from EPA/DHA than all the rest.</p><p></p><p><strong>alpha-Linolenic acid</strong>: This is another Omega-3 fatty acid. This is <strong>not</strong> useful for increasing brain function/mood. This is because it eventually gets converted to EPA and then DHA, but at an extremely non efficient conversion rate. What this is useful for is helping you get a better n-3/n-6 fatty acid ratio. Ideally in today's world you would want N-3/N-6 to be at a 1:1 ratio. With all the shitty fats they throw at us cheaply, if you can get your N-3/N-6 ratio at 1:2, that is one hell of an accomplishment. So what you want is Flax Oil supplements which have tons of alpha-Linolenic acid. No adverse effects from these in my usage, cheap over the counter. This way alpha-Linolenic acid can enter into competition at substrate binding since on enzymes that catalyze reactions with both n-3 and n-6 fatty acids(such as both of the cyclooxygenase isoforms. The n-6 fatty acids produce a lot more inflammation than n-3's and are not preferentially incorporated into brain membrane phosphatides like EPA and DHA are. Sorry for the length, I've kept this in layman's terms as much as possible.</p><p></p><p>The getting on a proper n-3 regimen will provide around 70% of the cognitive and mood enhancing benefits alone.</p><p></p><p><strong>Uridine</strong>: This is a nucleoside that is also part of the cycle that builds brain membrane phosphatides (for those so inclined it is called the Kennedy Cycle) Basically the brain enzymes that build membrane phosphatides and incorporate them into brain cells, most notably the synapses where neurons communicate with one another, (Thought to be the site targeted for enhancement by these supplements.)increase how fast they make the new structural components of brain cells. This is because they have a low affinity for these substrates(Uridine, Choline, EPA/DHA). Basically if you put more of this stuff in, you get more out, allowing brain cells to be much more versatile and have greater plasticity. There is also a secondary mechanism due to stimulation of one of the subtypes of purinergic receptors that aids in synaptogenesis.</p><p></p><p>Uridine accounts for roughly 20%</p><p></p><p>Unfortunately Uridine is a bit expensive and it has to be ordered from a special online store. There are a few and I don't recommend any of them over another as I have only tried one once. When I purchased it back in December it was roughly $50 for 25 grams. The ideal dose for me was 1g/day split into two 500mg. If you have all the other components of this trifecta on lock, you can get by with 500mg-750mg a day to save dough.</p><p></p><p></p><p><strong>Choline</strong>: (in the bitartrate form): Cheap as hell. I just picked up some today from GNC. $8.50 for 100 250mg tablets. I take 4 (1 gram) a day so this is a 25 day supply. Choline is another building block of brain membrane phospatides, so you get how this goes by now. We add each piece of the puzzle to complete the trifecta.</p><p></p><p>Choline accounts for perhaps 10% of the benefit alone.</p><p></p><p>If all of these supplements are combined, their whole is greater than the sum of each of their parts. Saturating the Kennedy Cycle enzymes along each step to creating the components of brain cells has additive effects.</p><p></p><p>I tried this full out with exactly the right dosages for about two months, then had to stop because I was too broke to afford the Uridine. While I was on it I felt incredibly clear headed, learning even 400 level math classes at university was a breeze.(Granted, they are not hard for me anyway, I just need to put a bit of studying in and pay attention in class.) But after about 4 weeks on this regimen I didn't need to really pay attention in class, taking notes went out the window. I just ended up bring some leisure reading in and half paying attention. I actually did better than before. The best part about it was that my mood felt so calm. On a 1-10 scale with 1 being ready to kill yourself and 10 full-blown mania, I never went below a 6. I was able to be happier when situations warranted it also.</p><p></p><p>Keep in mind, it takes at least 4 months before high dose EPA/DHA can kick in, so this is no quick fix, but once you get there it is worth it. All of these things are foods, you are just taking a larger amount</p></blockquote><p></p>
[QUOTE="I'mWaitingForTheMan, post: 68308, member: 2972"] Choline+Uridine+Fish Oil(Omega This is without a doubt the best natural combination brain booster out, and it has reasonably hard science behind it, as hard as you'll be liking to find as the field of cognitive enhancement is in its absolute infancy. [b]N-3(also known as Omega-3) Fatty acids[/b], are far and away the most essential ingredient in this triple threat combo. The [b]Only[/b] two of these fatty acids you want are EPA(Eicosapentaenoic acid) and DHA(Docosahexaenoic acid). What people don't realize is that you need [b]WAY[/b] more than an extra strength fish oil tablet to get the cognitive benefits, though you may still get the heart/cholesterol benefits from just a recommended serving. You need at least 3 [b]Grams[/b] of combined EPA/DHA to get the cognitive/mood benefits. [b]Always[/b] make sure the fish oil you buy states exactly how much EPA/DHA is in each serving, as those are the only two ingredient you are concerned with. Watch out for the serving size, sometimes they say each serving is 2 gel capsules, so do your math accordingly. When purchasing fish oil, shoot for the ones that say they are purified to remove mercury. From what I've read the mercury in fish stays in their meat/protein for the most part, so whatever makes it into the oil is negligible and then purified. This is probably safer than eating 5-6 servings of fish a week regarding mercury intake anyways. Keep in mind, some evidences suggests it is the ratio of n-3 fatty acids to n-6 that garners more neurocognitive improvement. This means you want to try to get more of your fats from EPA/DHA than all the rest. [b]alpha-Linolenic acid[/b]: This is another Omega-3 fatty acid. This is [b]not[/b] useful for increasing brain function/mood. This is because it eventually gets converted to EPA and then DHA, but at an extremely non efficient conversion rate. What this is useful for is helping you get a better n-3/n-6 fatty acid ratio. Ideally in today's world you would want N-3/N-6 to be at a 1:1 ratio. With all the shitty fats they throw at us cheaply, if you can get your N-3/N-6 ratio at 1:2, that is one hell of an accomplishment. So what you want is Flax Oil supplements which have tons of alpha-Linolenic acid. No adverse effects from these in my usage, cheap over the counter. This way alpha-Linolenic acid can enter into competition at substrate binding since on enzymes that catalyze reactions with both n-3 and n-6 fatty acids(such as both of the cyclooxygenase isoforms. The n-6 fatty acids produce a lot more inflammation than n-3's and are not preferentially incorporated into brain membrane phosphatides like EPA and DHA are. Sorry for the length, I've kept this in layman's terms as much as possible. The getting on a proper n-3 regimen will provide around 70% of the cognitive and mood enhancing benefits alone. [b]Uridine[/b]: This is a nucleoside that is also part of the cycle that builds brain membrane phosphatides (for those so inclined it is called the Kennedy Cycle) Basically the brain enzymes that build membrane phosphatides and incorporate them into brain cells, most notably the synapses where neurons communicate with one another, (Thought to be the site targeted for enhancement by these supplements.)increase how fast they make the new structural components of brain cells. This is because they have a low affinity for these substrates(Uridine, Choline, EPA/DHA). Basically if you put more of this stuff in, you get more out, allowing brain cells to be much more versatile and have greater plasticity. There is also a secondary mechanism due to stimulation of one of the subtypes of purinergic receptors that aids in synaptogenesis. Uridine accounts for roughly 20% Unfortunately Uridine is a bit expensive and it has to be ordered from a special online store. There are a few and I don't recommend any of them over another as I have only tried one once. When I purchased it back in December it was roughly $50 for 25 grams. The ideal dose for me was 1g/day split into two 500mg. If you have all the other components of this trifecta on lock, you can get by with 500mg-750mg a day to save dough. [b]Choline[/b]: (in the bitartrate form): Cheap as hell. I just picked up some today from GNC. $8.50 for 100 250mg tablets. I take 4 (1 gram) a day so this is a 25 day supply. Choline is another building block of brain membrane phospatides, so you get how this goes by now. We add each piece of the puzzle to complete the trifecta. Choline accounts for perhaps 10% of the benefit alone. If all of these supplements are combined, their whole is greater than the sum of each of their parts. Saturating the Kennedy Cycle enzymes along each step to creating the components of brain cells has additive effects. I tried this full out with exactly the right dosages for about two months, then had to stop because I was too broke to afford the Uridine. While I was on it I felt incredibly clear headed, learning even 400 level math classes at university was a breeze.(Granted, they are not hard for me anyway, I just need to put a bit of studying in and pay attention in class.) But after about 4 weeks on this regimen I didn't need to really pay attention in class, taking notes went out the window. I just ended up bring some leisure reading in and half paying attention. I actually did better than before. The best part about it was that my mood felt so calm. On a 1-10 scale with 1 being ready to kill yourself and 10 full-blown mania, I never went below a 6. I was able to be happier when situations warranted it also. Keep in mind, it takes at least 4 months before high dose EPA/DHA can kick in, so this is no quick fix, but once you get there it is worth it. All of these things are foods, you are just taking a larger amount [/QUOTE]
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